A novel treatment for liver injury by modulation oflipid mediator effects
A novel treatment for liver injury by modulation oflipid mediator effects
批准号:
22590716
负责人:
IKEDA Hitoshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
关键词:
中文摘要
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英文摘要
Portal hypertension is well known as one of critical complications of liver cirrhosis. We have successfully treated portal hypertension in rodent models by inhibiting an effect of sphingosine 1-phosphate, a lipid mediator, with its receptor antagonist. Because our strategy had minimal side effects such as a reduction of arterial pressure, its application in human should be further examined.
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Liver involvement in sphingosine 1-phosphate dynamism revealed by adeniviral hepatic overexpression of apolipoprotein M.
载脂蛋白 M 的腺病毒肝脏过度表达揭示了肝脏参与 1-磷酸鞘氨醇动力学。
DOI:
--
发表时间:
2013
期刊:
Atherosclerosis
影响因子:
5.3
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y.]
通讯作者:
Yatomi Y.
門脈圧亢進症におけるスフィンゴシン1リン酸の関与
1-磷酸鞘氨醇与门脉高压的关系
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y., Takuwa Y, Kegeyama Y, 池田均, 池田均]
通讯作者:
池田均
受容体SIP2を介したスフィンゴシン1リン酸作用抑制による門脈圧亢進症治療の可能性
通过受体 SIP2 抑制 1-磷酸鞘氨醇作用来治疗门静脉高压症的可能性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y., Takuwa Y, Kegeyama Y, 池田均, 池田均, 池田均]
通讯作者:
池田均
リゾリン脂質と肝臓疾患
溶血磷脂与肝脏疾病
DOI:
--
发表时间:
2012
期刊:
臨床検査
影响因子:
--
作者:
[Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y., Takuwa Y, Kegeyama Y, 池田均]
通讯作者:
池田均
Elucidation of a role of sphingosine 1-phosphate on liver damage
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批准号:19590750
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2007
-
负责人:IKEDA Hitoshi
-
依托单位:
Elucidation of the clinical significance of autotaxin and lysophosphatidic acid in liver diseases.
-
批准号:17590618
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2005
-
负责人:IKEDA Hitoshi
-
依托单位:
Mechanisms of Hepatoblastoma Carcinogenesis in Low Birth Weight Infants
-
批准号:15591892
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2003
-
负责人:IKEDA Hitoshi
-
依托单位:
Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regeneration
-
批准号:14570451
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2002
-
负责人:IKEDA Hitoshi
-
依托单位:
-General Study of the Chinese Agriculture and Rural Economy after joining World Trade Organization-
-
批准号:14402031
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.62万
-
财政年份:2002
-
负责人:IKEDA Hitoshi
-
依托单位:
PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGY
-
批准号:12670461
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2000
-
负责人:IKEDA Hitoshi
-
依托单位:
Pathogenetic roles of human endogenous retroviruses in autoimmune diseases
-
批准号:12670193
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2000
-
负责人:IKEDA Hitoshi
-
依托单位:
ELUCIDATION OF SIGNIFICANCE OF c-met EXPRESSION IN ACTIVATED HEPATIC STELLATE GELLS AND ITS APPLICATION OF THERAPEUTIC STRATEGY
-
批准号:09670517
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:IKEDA Hitoshi
-
依托单位:
Mapping of the gene for Holmes' ataxia by searching of triplet repeats
-
批准号:09470057
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.65万
-
财政年份:1997
-
负责人:IKEDA Hitoshi
-
依托单位:
Platelet Epidermal Growth Factor and Liver Regeneration
-
批准号:62570313
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1987
-
负责人:IKEDA Hitoshi
-
依托单位:
海外基金