Investigations of painmechanism related to ATP receptors aiming at new analgesics for cancer pain

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We investigated the effects of several analgesics on many subtypes of ATP receptors, and revealed that local anesthetics, lidocaine inhibited the function of P2×7,0ne of the ATP receptor subtypes. We demonstrated that this effect happen through direct effect of lidocaine on P2×_7 receptor, and is non-competitive inhibition. These results suggest that inhibition of P2×_7 function by lidocaine is one of the mechanisnls of analgesic effects by lidocaine for cancer pain, which are still unknown, and indicate the possibility of development of new analgesics for cancer pain by further research about this mechanism.