Investigations of painmechanism related to ATP receptors aiming at new analgesics for cancer pain

本文研究了几种镇痛药对多种ATP受体亚型的作用，发现局麻药利多卡因可抑制ATP受体亚型的P2× 7.0ne功能。我们证明这种作用是通过利多卡因对P2× 7受体的直接作用而发生的，并且是非竞争性抑制。提示利多卡因抑制P2×_7功能是其镇痛作用机制之一，但其机制尚不清楚。进一步研究利多卡因的镇痛机制，有可能开发新的癌痛镇痛药。

We investigated the effects of several analgesics on many subtypes of ATP receptors, and revealed that local anesthetics, lidocaine inhibited the function of P2×7,0ne of the ATP receptor subtypes. We demonstrated that this effect happen through direct effect of lidocaine on P2×_7 receptor, and is non-competitive inhibition. These results suggest that inhibition of P2×_7 function by lidocaine is one of the mechanisnls of analgesic effects by lidocaine for cancer pain, which are still unknown, and indicate the possibility of development of new analgesics for cancer pain by further research about this mechanism.