Investigations of painmechanism related to ATP receptors aiming at new analgesics for cancer pain

我们研究了几种镇痛药对许多ATP受体亚型的影响，发现局麻药利多卡因抑制了ATP受体亚型P2×7的功能。我们证明这种作用是通过利多卡因对P2×_7受体的直接作用而发生的，并且是一种非竞争性抑制。这些结果提示，利多卡因对P2×_7功能的抑制是利多卡因对癌痛镇痛作用的机制之一，目前尚不清楚，并提示通过对这一机制的进一步研究，有可能开发出新的癌痛镇痛药物。

We investigated the effects of several analgesics on many subtypes of ATP receptors, and revealed that local anesthetics, lidocaine inhibited the function of P2×7,0ne of the ATP receptor subtypes. We demonstrated that this effect happen through direct effect of lidocaine on P2×_7 receptor, and is non-competitive inhibition. These results suggest that inhibition of P2×_7 function by lidocaine is one of the mechanisnls of analgesic effects by lidocaine for cancer pain, which are still unknown, and indicate the possibility of development of new analgesics for cancer pain by further research about this mechanism.