The effect of HGF on MMP-9 expression in human meningeal cells; Toward the development of novel therapeutic strategies for posthemorrhagic hydrocephalus

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We treated cultured human meningeal cells with human recombinant HGF and TGF-beta1. We found that the expression of MMP-9 was enhanced by HGF, most probably through the activation of the ERK1/2 and PI3K signaling pathways. And more, we found that TGF-beta1 enhances the effect of HGF on MMP-9 expression in human meningeal cells. Our present data may provide an impetus for the development of therapies targeting MMP-9 or HGF, which will eliminate the need for a shunt operation in PHH patients.