Inhibition of Fibrosis and Inflammation by Triple Therapy with Pirfenidone, Edaravone, and Erythropoietin in Rabbits with Drug-Induced Lung Injury : Computed Tomography-Pathological Correlation

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We divided drug-induced lung injury rabbits into 3groups ; the control group(G1), pirfenidone group(G2), and a three-drug combination group(G3)(pirfenidone, edaravone, and erythropoietin). CT on day 28, G3 tended to exhibit a smaller area with abnormal opacity compared with G1(p=0. 071). In microscopic specimens, the average fibrosis score showed a significant difference between G1 and G3(p<0. 05). Moreover, the average fibrosis score tended to be smaller in G3 than in G2(p<0. 1).From the above, administration of pirfenidone alone suppressed the advancement of drug-induced lung injury, but the three-drug combination prevented further progression.