Activation of Remote Carbon-Hydrogen Bond Based on the Creation of Functionalized Transition Metal Complexes

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In this research, novel transition metal complexes bearing a substrate-binding moiety and a substrate-activating moiety on a rigid carbon backbone were designed to realize regioselective remote C-H bond activation. Thus, naphthalene derivatives which contain a bipyridine moiety for substrate-activation and a benzoindole moiety or a phenol moiety for substrate-binding were prepared and phenyl-substituted carboxylic acids or alcohols were introduced as substrate into the molecules. Borylation reaction was examined employing these substrates and only meta-borylated aromatic compounds were selectively produced. Thus these complexes recognize the specific C-H bond of substrates, which can not be realized by conventional methods.