Investigation of gastric cancer chemoprevention after Helicobacter pylori eradication using rodent models

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Although eradication therapy of Helicobacter pylori(H. pylori) has been shown to be effective for the prevention of stomach cancer, the prevention method of gastric carcinogenesis after eradication remains to be developed. In this study, we investigated the inhibitory effect of aspirin on gastric cancer after eradication using H. pylori-infected Mongolian gerbil model. We confirmed that MON/Jms strain is susceptible to H. pylori and develops severe chronic gastritis. As the long-term experiment, the MON/Jms gerbils were intra-gastrically infected with H. pylori, treated with chemical carcinogen, eradication at 36th week, and fed diet containing aspirin. Further examinations are planned to examine the chemopreventive effects of aspirin on the incidence of gastric tumor after eradication.