Preventive effects of geriatric and life-style related diseases by oral administration of a novel hydrogen-producing material

口服新型产氢材料对老年和生活方式相关疾病的预防作用

• 批准号: 23300257
• 负责人: OHTA Shigeo
• 金额: $ 11.07万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300257/
• 关键词: 生活習慣病; ミトコンドリア; 酸化ストレス; 水素; 水素吸蔵金属; エネルギー代謝

MgH2 produces molecular hydrogen (H2) by reacting with water. Safety of MgH2 was confirmed by excess oral administration in long term in mice. Hydrogen was increased in the blood in rats after oral administration of MgH2. The oral administration of MgH2 effectively reduced blood triglyceride in 2-type diabetic model mice. To investigate the molecular mechanism, the change in gene expression between before and after its administration was comprehensively analyzed by using microarray. As the results, following the increase in PGC-1alpha expression increased expressions in genes involved in fatty acid and cholesterol metabolism. Thus, this study suggests the preventive effects of oral administration of MgH2 in lifestyle related diseases in model mice.

MgH2通过与水反应产生分子氢（H2）。通过小鼠长期过量口服，证实了MgH2的安全性。口服MgH2后，大鼠血液中氢含量升高。口服MgH2可有效降低2型糖尿病模型小鼠血甘油三酯。为探究其分子机制，采用芯片技术综合分析给药前后基因表达的变化。结果表明，随着PGC-1alpha表达的增加，脂肪酸和胆固醇代谢相关基因的表达也随之增加。因此，本研究提示口服MgH2对模型小鼠生活方式相关疾病的预防作用。

项目成果

Hydrogen Medcine Group : Molecular Hydrogen Prevents Learning- and Memory-deficits Declined by Physical Restraint Stress

氢医学组：氢分子可预防因身体束缚压力而导致的学习和记忆缺陷

• 发表时间: 2013
• 作者: Ohta S;Nakao A;Ohno K;Ohta S;Shigeo Ohta;太田成男;太田成男;太田成男;ShigeoOhta;太田成男;太田成男;Shigeo Ohta;太田成男;太田成男;太田成男;Shigeo Ohta
• 通讯作者: Shigeo Ohta

水素による抗酸化作用とアンチエイジング効果

氢的抗氧化和抗衰老作用

• 发表时间: 2013
• 作者: Yokota T;Nishimaki K;Ohsawa I;Ohta S.;太田成男
• 通讯作者: 太田成男

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide.

• DOI: 10.1186/2045-9912-1-18
• 发表时间: 2011-08-04
• 期刊: Medical gas research
• 影响因子: 2.9
• 作者: Hanaoka T;Kamimura N;Yokota T;Takai S;Ohta S
• 通讯作者: Ohta S

Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS

牛磺酸可改善 MELAS 患者受损的线粒体功能并预防中风样发作

• 发表时间: 2012
• 期刊: Intern. Med
• 作者: Rikimaru M;Ohsawa Y;Wolf AM;Nishimaki K;Ichimiya H;Kamimura N;Nishimatsu S;Ohta S;Sunada Y
• 通讯作者: Sunada Y

APP transgenic mice with oxidative stress. The 11th International Conference AD/PD 2013

具有氧化应激的APP转基因小鼠。

• 发表时间: 2013
• 作者: Aoyagi Y.;Shephard R.J;太田成男;片平理子 上村協子;松田文子;岡田浩介;中井孝章;藤野次雄;呉 世昶;松田文子 池上徹 竹内由利子 水野有希 茂木伸之 吉川徹 酒井一博;Naomi Kamimura et al.
• 通讯作者: Naomi Kamimura et al.