Role of phospholipase C epsilon in ultraviolet-induced skin carcinogenesis, skin inflammation, cataract, and psoriasis

磷脂酶 C epsilon 在紫外线诱发的皮肤癌、皮肤炎症、白内障和牛皮癣中的作用

• 批准号: 23591645
• 负责人: OKA Masahiro
• 金额: $ 3.33万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591645/
• 关键词: ホスホリパーゼＣ; 紫外線; 皮膚; 乾癬; 発癌; 白内障; マウス; 角膜; ホスホリパーゼC イプシロン; 創傷治癒; 好中球; ホスホリパーゼCε; 皮膚発癌; 皮膚炎症; ホスホリパーゼCイプシロン; 炎症

Phospholipase C (PLC) epsilon is a phosphoinositide-specific PLC regulated by small GTPases including Ras and Rap. In order to investigate the role of PLCe in the skin, we created transgenic mice overexpressing PLCe in epidermal leratinocytes (K5-PLCe-TG). The resulting transgenic mice spontaneously developed skin inflammation as characterized by formation of adherent silvery scales, acanthosis, parakeratosis, and infiltration of neutrophils in the epidermis, and aberrant infiltration of immune cells such as T cells and dendritic cells. When mice were irradiated with ultraviolet B, most wild mice developed erosions and ulcers in the skin, whereas the K5-PLCe-TG mice were resistant to UVB-induced skin damages. In addition, it was revealed that the ability of wound healing in the K5-PLCe-TG mice is increased compared to that in wild mice.

磷脂酶C（PLC）是由Ras和Rap等小GTP酶调控的磷酸肌醇特异性PLC。为了研究PLCe在皮肤中的作用，我们建立了在表皮角质形成细胞中过表达PLCe的转基因小鼠（K5-PLCe-TG）。所得转基因小鼠自发地发展皮肤炎症，其特征在于形成粘附的银色鳞片、棘皮症、角化不全和表皮中嗜中性粒细胞的浸润，以及免疫细胞如T细胞和树突细胞的异常浸润。 当用紫外线B照射小鼠时，大多数野生小鼠皮肤出现糜烂和溃疡，而K5-PLCe-TG小鼠对UVB诱导的皮肤损伤具有抵抗力。此外，与野生小鼠相比，K5-PLCe-TG小鼠的伤口愈合能力增强。

项目成果

乾癬患者におけるアダリムマブまたはインフリキシマブの中和抗体と治療効果に対する検討

银屑病患者中和抗体及阿达木单抗或英夫利昔单抗治疗效果的研究

• 发表时间: 2012
• 作者: 西川里香;尾藤利憲;畠山真弓;菊澤亜夕子;神吉晴久;永井宏;岡昌宏;錦織千佳子;池田哲哉;堀川達弥;足立厚子;皿山泰子;吉崎仁胤;瀬戸英伸
• 通讯作者: 瀬戸英伸

Prolonged varicella-zoster virus reinfection in an adult after unrelated cord blood transplantation.

• DOI: 10.4103/0019-5154.100500
• 发表时间: 2012-09
• 期刊: Indian journal of dermatology
• 影响因子: 1.7
• 作者: Oka M;Kunisada M;Oba Y;Okamura A;Nishigori C
• 通讯作者: Nishigori C

Severe xanthomatosis with prominent tuberous xanthomas on the cheeks and the nasal dorsum in a patient with type IIa hyperlipoproteinemia.

患有 IIa 型高脂蛋白血症的患者患有严重黄瘤病，脸颊和鼻背上有明显的结节性黄瘤。

• DOI: 10.1684/ejd.2013.2063
• 发表时间: 2013
• 期刊: Eur. J. Dermatol.
• 作者: Fujiwara;S.;Oka;M.;Kunisada;M.;Honjo;K.;Nishigori;C.
• 通讯作者: C.

Phospholipase Cε has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC

• DOI: 10.1038/labinvest.2011.10
• 发表时间: 2011-05-01
• 期刊: LABORATORY INVESTIGATION
• 影响因子: 5
• 作者: Oka, Masahiro;Edamatsu, Hironori;Nishigori, Chikako
• 通讯作者: Nishigori, Chikako

Unilateral eruptive seborrheic keratoses associated with hepatic hemangiomas.

与肝血管瘤相关的单侧爆发性脂溢性角化病。

• DOI: 10.1684/ejd.2013.2229
• 发表时间: 2014
• 期刊: Eur. J. Dermatol.
• 作者: Ikkaku;N.;Oka;M.;Yamada;Y.;Uda;K.;Nishigori;C.
• 通讯作者: C.