Effects of Newly synthetized antioxydant DHLHZn on Bleomycine induced pulmonary fibrosis
Effects of Newly synthetized antioxydant DHLHZn on Bleomycine induced pulmonary fibrosis
批准号:
23592673
负责人:
NOGUCHI Takayuki
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
This study investigated the reduction in acute pulmonary fibrosis after Sodium Zinc Histidine Dithiooctanamide (DHL-HisZn) which was the zinc chelate of the alpha-lipoic acid derivative of the de novo synthesis, to inhibit oxidative stress induced by bleomycin in a rat model. After the administration of bleomycin, the animals were sacrificed and lung and serum samples were harvested and evaluated. This study results indicate that treatment with DHL-HisZn can alleviate pulmonary fibrosis in a model of bleomycin.
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会议论文
新規αリポ酸誘導体DHL-HisZnを用いたブレオマイシン誘発肺線維症モデルでの治療効果の検討
使用新型 α-硫辛酸衍生物 DHL-HisZn 检查博来霉素诱导的肺纤维化模型的治疗效果
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[藤田和也]
通讯作者:
藤田和也
肺線維化疾患の予防または治療薬
肺纤维化疾病的预防剂或治疗剂
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
αリポ酸誘導体およびビタミンE誘導体の可能性
α硫辛酸衍生物和维生素E衍生物的潜力
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[野口隆之]
通讯作者:
野口隆之
Activation of sensory neurons reduces ischemia/ reperfusion-induced acute renal injury in rats
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批准号:19592092
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
-
负责人:NOGUCHI Takayuki
-
依托单位:
Effect of abnormal body temperature on ventilator induced lung injury and acute phase reaction
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批准号:18591710
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:2006
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负责人:NOGUCHI Takayuki
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依托单位:
EFFECTS OF MILD HYPOTHERMIA ON VENTILATOR LUNG INJURY AND RAT ACID-INDUCED ACUTE LUNG INJURY MODEL
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批准号:14571449
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:NOGUCHI Takayuki
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依托单位:
MILD HYPOTHERMIA ATTENUATES RAT ACID-INDUCED ACUTE LUNG INJURY MODEL
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批准号:12671481
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2000
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负责人:NOGUCHI Takayuki
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依托单位:
EFFECTS OF INTESTINAL LAVAGE ON PATIENTS WITH SEPTIC MULTIPLE ORGAN FAILURE
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批准号:10671425
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1998
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负责人:NOGUCHI Takayuki
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依托单位:
海外基金