Functional analysis of novel food factors which activate anti-obese receptor for bile acids
Functional analysis of novel food factors which activate anti-obese receptor for bile acids
批准号:
23780127
负责人:
SHIMIZU Makoto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
TGR5 is a member of G protein-coupled receptor which is activated by bile acids, and has been reported its anti-obese and anti-diabetic effects. The screening experiments using food factor library identified some food factors, including nomilin, activate TGR5. From animal studies, we found that nomilin improved high fat diet-induced obesity and hyperglycemia, suggesting nomilin may contribute to an improvement of metabolic syndrome. We also found that another food factor (factor A), which activates TGR5, decreased body weight gain by high fat diet.
期刊论文(0)
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科研奖励(0)
会议论文
TGR5を活性化する新規化合物の機能解析
激活 TGR5 的新化合物的功能分析
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[村井正俊, 白石悠祐, 崎山直人, 三芳秀人, 清水誠]
通讯作者:
清水誠
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依托单位:
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Exploration into Double Nucleophilic Addition Reaction to α, β- Unsaturated Aldimines Promoted by Titanium Tetrahalides
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Science Teacher's Preconception and Teacher Education Program and Development of the Teaching and Learning Model
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-
财政年份:1998
-
负责人:SHIMIZU Makoto
-
依托单位:
国内基金
海外基金
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