Molecular analysis of intestinal stress induction and regulation of the stress by food factors
Molecular analysis of intestinal stress induction and regulation of the stress by food factors
批准号:
20248013
负责人:
SHIMIZU Makoto
金额:
$30.45万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Inflammatory reactions induced by various stresses in the intestinal epithelium were investigated from the viewpoint of cell-cell interaction. Interaction between intestinal epithelial cells and immune cells was analyzed using in vitro cell culture model systems newly constructed in this study. Food substances that could suppress inflammatory reactions were also searched using these systems. Activated macrophages and mast cells induced damage to epithelial cells, whereas epithelial cells induced differentiation and functional activation of mast cells. Certain molecules responsible for the cell-cell interactions and food factors with anti-inflammatory functions were successfully found.
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腸管上皮細胞のサイトカイン産生に対するスフィンゴシン-1-リン酸の作用
1-磷酸鞘氨醇对肠上皮细胞细胞因子产生的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[岩本拓, 戸塚護, 清水誠, 薩秀夫]
通讯作者:
薩秀夫
ゲラニインがマウス小腸上皮細胞株のToll様受容体リガンド刺激で誘導されるインターロイキン6産生に与える影響
天竺葵苷对 Toll 样受体配体刺激诱导的小鼠小肠上皮细胞系白细胞介素 6 产生的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[尾形悠, 岩本拓, 伊東秀之, 波多野力, 清水誠, 戸塚護]
通讯作者:
戸塚護
Suppressive effect of an isoflavone fraction on tumor necrosis factor-α-induced interleukin-8 produciton in human intestinal epithelial Caco-2 cells
异黄酮组分对人肠上皮 Caco-2 细胞中肿瘤坏死因子-α 诱导的白细胞介素 8 产生的抑制作用
DOI:
--
发表时间:
2009
期刊:
J.Nutr.Sci.Vitaminol. 55
影响因子:
--
作者:
[Satsu H., Hyun J.S., Shin H.S., Shimizu M.]
通讯作者:
Shimizu M.
マクロファージ様細胞との複合培養により腸管上皮細胞が受ける障害の機構解析
巨噬细胞样细胞复合培养对肠上皮细胞损伤的机制分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[石本容子, 薩秀夫, 望月鉄之祐, 戸塚護, 清水誠]
通讯作者:
清水誠
腸管上皮細胞における炎症と食品成分によるその制御
肠上皮细胞炎症及其受食物成分的控制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[瀬戸東有香, 浜地貴志, 葉山真歩子, 茂木祐子, 野崎久義, 柳田洋平, 清水誠]
通讯作者:
清水誠
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