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Molecular analysis of skin cell activation by orally administered functional food substances

Molecular analysis of skin cell activation by orally administered functional food substances
口服功能性食品物质激活皮肤细胞的分子分析
批准号:
23380072
负责人:
SHIMIZU Makoto
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
Gene expression changes induced in damaged mice skin by Mg-deficient diet or UV irradiation were elucidated by DNA microarray and PCR analyses. Oral administration of ECM components, such as ceramide and collagen, was found to attenuate the gene expression changes. In vitro experiments using a fibroblast-keratinocyte co-culture system constructed with mouse primary skin cells or human skin cell lines showed that metabolites of ceramide as well as collagen peptides induced similar effects on gene expression of skin cells. These results suggest that ECM components are digested and/or metabolized after oral administration, reach the skin tissue, and then affect keratinocyte functions via modulating fibroblast-keratinocyte interactions.
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神经酰胺对共培养系统中皮肤细胞的影响
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [赤木 裕, レ ヴ ラン フォン, 薩 秀夫, 戸塚 護, 千田和広, 清水 誠]
通讯作者: 清水 誠
Organotypic coculture of mouse skin cells as a model for studying the effects of collagen peptide
小鼠皮肤细胞的器官型共培养作为研究胶原蛋白肽作用的模型
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Phuong, L.V., Takatori. R., Iwamoto,T., Sato, K., Totsuka,M., Satsu, H., Chida,K., Shimizu, M]
通讯作者: M
Effects of prolyl-hydroxyproline, a collagen peptide, on gene expression of mouse skin cells in coculture
胶原肽脯氨酰羟脯氨酸对共培养小鼠皮肤细胞基因表达的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Phuong, L.V., Takatori. R., Iwamoto,T., Sato, K., Totsuka,M., Satsu, H., Chida,K., Shimizu, M]
通讯作者: M
Effects of prolyl-hydroxyproline, a collagen peptide, on gene expression of mouse skin cells in co-culture
胶原肽脯氨酰羟脯氨酸对共培养小鼠皮肤细胞基因表达的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Phuong, L.V]
通讯作者: L.V
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