An on-chip hepatic metabolism model for pharmacokinetic studies
An on-chip hepatic metabolism model for pharmacokinetic studies
批准号:
24710141
负责人:
KIMURA Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
In this project, we have established novel microfluidic technologies toward an in vitro metabolism assay platform as an alternative method of animal tests. 1) A fabrication method of an encapsulated three-dimensional cell structure in the microfluidics has been proposed to construct the metabolism model by a biomimetic approaches. 2) An microfluidic device to evaluate functions of the metabolism model has been developed, and the performance of the device was successfully tested using a prodrug.
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代謝経路を再現するオンチップ生体モデルの構築
构建重现代谢途径的片上生物模型
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[堀尾直史, 木村啓志]
通讯作者:
木村啓志
定量生物学研究者のためのマイクロ流体デバイス技術
适用于定量生物学研究人员的微流控装置技术
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[高橋康史, 熊谷明哉, 棟方裕一, 伊野浩介, 珠玖仁, 金村聖志, 末永智一, 木村啓志]
通讯作者:
木村啓志
DOI:
10.1016/j.jbiosc.2013.11.019
发表时间:
2014-06-01
期刊:
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
影响因子:
2.8
作者:
[Nakayama, Hidenari, Kimura, Hiroshi, Sakai, Yasuyuki]
通讯作者:
Sakai, Yasuyuki
着床前胚を取り扱うマイクロ流体デバイス技術
用于处理植入前胚胎的微流体装置技术
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[H. Honma, K. Takahashi, M. Ishida, and K. Sawada, 木村啓志]
通讯作者:
木村啓志
マイクロ流体デバイスを用いた細胞外環境操作
使用微流体装置操纵细胞外环境
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Ino, K., Kanno, Y., Arai, T., Inoue, K. Y., Takahashi, Y., Shiku, H., Matsue, T., 本間浩章,高橋一浩,石井仁,石田誠,澤田和明, 木村啓志]
通讯作者:
木村啓志
共 16 条
Cell therapy against intractable EB virus infection using immunological tolerance
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批准号:24659493
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:KIMURA Hiroshi
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依托单位:
The decreases in hypoxic ventilatory response affect acute exacerbation in patients with respiratory failure and/or obesity hypoventilation syndrome
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批准号:23591158
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:KIMURA Hiroshi
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依托单位:
Live cell imaging of histone methylation and inactive X chromosome dynamics
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批准号:22370063
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
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财政年份:2010
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负责人:KIMURA Hiroshi
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依托单位:
Integrated "Body on a Chip" system for cell-based assay
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批准号:22710120
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:KIMURA Hiroshi
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依托单位:
Science and Technology Studies to Develop the Governance for Effective Use of Nuclear Energy
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批准号:21360464
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
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财政年份:2009
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负责人:KIMURA Hiroshi
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依托单位:
Diagnosis and pathogenetic analysis using a novel identification method for EBV-infected cells
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批准号:21591384
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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负责人:KIMURA Hiroshi
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依托单位:
Infrared Spectra of Comets as a Barometer for Their Evolution
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批准号:21340040
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.81万
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财政年份:2009
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负责人:KIMURA Hiroshi
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依托单位:
Basic Researches to reexamine Problem Group called the Absolute and a Place, from the Perspective of an Image and a Field
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批准号:21520040
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.08万
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财政年份:2009
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负责人:KIMURA Hiroshi
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依托单位:
Relative dielectric constant measurement system for natural soil in microwave region
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批准号:20560393
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2008
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负责人:KIMURA Hiroshi
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依托单位:
Functional morphologic study of the peripheral cholinergic nervous system in human.
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批准号:20390051
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.4万
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财政年份:2008
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负责人:KIMURA Hiroshi
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依托单位:
The structure and dynamics of chromatin harboring specific histone modifications
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批准号:19370076
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.65万
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财政年份:2007
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负责人:KIMURA Hiroshi
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依托单位:
Integration of legged locomotion control methods and understanding of motion intelligence from the view points of both mechanics and control
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批准号:19500166
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2007
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负责人:KIMURA Hiroshi
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依托单位:
Hypoxic stress in sleep apnea causes systemic inflammation and promotes atherosclerosis.
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批准号:19390226
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.65万
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财政年份:2007
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负责人:KIMURA Hiroshi
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依托单位:
Biosyntehsis and Properties of Copolyesters with 4-Hydroxyalkanoic Acid Unit
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批准号:16550133
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2004
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负责人:KIMURA Hiroshi
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依托单位:
Molecular mechanisms of chromatin formation and dynamics
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批准号:16084202
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$83.2万
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财政年份:2004
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负责人:KIMURA Hiroshi
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依托单位:
Regulation of gene expression and chromatin dynamics in living cells
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批准号:15370073
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.92万
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财政年份:2003
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负责人:KIMURA Hiroshi
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依托单位:
Hypoxic stress and atherosclerosis in patients with sleep apnea-hypopnea syndrome
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批准号:15590821
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2003
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负责人:KIMURA Hiroshi
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依托单位:
Research on the generation mechanism of the behavior intelligence for a quadruped robot assisting the disabilities
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批准号:15500104
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.73万
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财政年份:2003
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负责人:KIMURA Hiroshi
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依托单位:
Pathogenesis on reactivation of viral infections in immunocompromised hosts and its prophylaxis and therapy.
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批准号:13670793
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:2001
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负责人:KIMURA Hiroshi
-
依托单位:
Assessment using hydra of endocrine disruptors contaminated in freshwater environment
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批准号:13680623
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:2001
-
负责人:KIMURA Hiroshi
-
依托单位: