Cell therapy against intractable EB virus infection using immunological tolerance
Cell therapy against intractable EB virus infection using immunological tolerance
批准号:
24659493
负责人:
KIMURA Hiroshi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
Severe Epstein-Barr virus (EBV) infections, such as chronic active EBV infection and EBV-associated hemophagocytic lymphohistiocytosis, are refractory to therapies and intractable diseases. Recently, fetal-maternal lymphohematopoietic microchimerism can be detected in blood from healthy individuals, and immunological tolerance exists between mothers and children. In this study, in order to develop novel therapies for severe EBV infections, fundamental studies including the proof of fetomaternal microchimerism have been performed for establishing cell therapy.
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難治性EBウイルス感染症~EBV-HLHとCAEBVの病態から治療まで~ : CAEBV~アジア型と欧米型~
难治性EB病毒感染~从EBV-HLH和CAEBV的病理到治疗~:CAEBV~亚洲型和西方型~
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kawada JI, Ito Y, Iwata S, Kawano Y, Kanazawa T, Siddiquey MN, and Kimura H., 木村宏, 木村宏]
通讯作者:
木村宏
A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation
同种异体外周血干细胞移植后EB病毒感染的自然杀伤细胞的单克隆扩增
DOI:
10.1016/j.jcv.2012.11.004
发表时间:
2013
期刊:
J Clin Virol
影响因子:
8.8
作者:
[Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N]
通讯作者:
Komatsu N
Interleukin-17A-Producing T Lymphocytes in Chronic Active Epstein-Barr Virus Infection.
慢性活动性 Epstein-Barr 病毒感染中产生白细胞介素 17A 的 T 淋巴细胞。
DOI:
10.1111/1348-0421.12010
发表时间:
2013
期刊:
Microbiology and Immunology
影响因子:
2.6
作者:
[Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N., Ohta R]
通讯作者:
Ohta R
ウイルス学の基礎よりみた臓器移植後の感染症
从病毒学基础看器官移植后的传染病
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kawada JI, Ito Y, Iwata S, Kawano Y, Kanazawa T, Siddiquey MN, and Kimura H., 木村宏, 木村宏, 木村宏, 木村宏, 木村宏]
通讯作者:
木村宏
ウイルス感染細胞の検出・同定法及びキット
病毒感染细胞检测/鉴定方法及试剂盒
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 14 条
An on-chip hepatic metabolism model for pharmacokinetic studies
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批准号:24710141
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.91万
-
财政年份:2012
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负责人:KIMURA Hiroshi
-
依托单位:
The decreases in hypoxic ventilatory response affect acute exacerbation in patients with respiratory failure and/or obesity hypoventilation syndrome
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批准号:23591158
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:KIMURA Hiroshi
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依托单位:
Live cell imaging of histone methylation and inactive X chromosome dynamics
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批准号:22370063
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
-
财政年份:2010
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负责人:KIMURA Hiroshi
-
依托单位:
Integrated "Body on a Chip" system for cell-based assay
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批准号:22710120
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2010
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负责人:KIMURA Hiroshi
-
依托单位:
Science and Technology Studies to Develop the Governance for Effective Use of Nuclear Energy
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批准号:21360464
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2009
-
负责人:KIMURA Hiroshi
-
依托单位:
Diagnosis and pathogenetic analysis using a novel identification method for EBV-infected cells
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批准号:21591384
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:KIMURA Hiroshi
-
依托单位:
Basic Researches to reexamine Problem Group called the Absolute and a Place, from the Perspective of an Image and a Field
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批准号:21520040
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.08万
-
财政年份:2009
-
负责人:KIMURA Hiroshi
-
依托单位:
Infrared Spectra of Comets as a Barometer for Their Evolution
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批准号:21340040
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.81万
-
财政年份:2009
-
负责人:KIMURA Hiroshi
-
依托单位:
Relative dielectric constant measurement system for natural soil in microwave region
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批准号:20560393
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2008
-
负责人:KIMURA Hiroshi
-
依托单位:
Functional morphologic study of the peripheral cholinergic nervous system in human.
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批准号:20390051
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.4万
-
财政年份:2008
-
负责人:KIMURA Hiroshi
-
依托单位:
The structure and dynamics of chromatin harboring specific histone modifications
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批准号:19370076
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.65万
-
财政年份:2007
-
负责人:KIMURA Hiroshi
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依托单位:
Integration of legged locomotion control methods and understanding of motion intelligence from the view points of both mechanics and control
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批准号:19500166
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2007
-
负责人:KIMURA Hiroshi
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依托单位:
Hypoxic stress in sleep apnea causes systemic inflammation and promotes atherosclerosis.
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批准号:19390226
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.65万
-
财政年份:2007
-
负责人:KIMURA Hiroshi
-
依托单位:
Biosyntehsis and Properties of Copolyesters with 4-Hydroxyalkanoic Acid Unit
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批准号:16550133
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2004
-
负责人:KIMURA Hiroshi
-
依托单位:
Molecular mechanisms of chromatin formation and dynamics
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批准号:16084202
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$83.2万
-
财政年份:2004
-
负责人:KIMURA Hiroshi
-
依托单位:
Research on the generation mechanism of the behavior intelligence for a quadruped robot assisting the disabilities
-
批准号:15500104
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:2003
-
负责人:KIMURA Hiroshi
-
依托单位:
Hypoxic stress and atherosclerosis in patients with sleep apnea-hypopnea syndrome
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批准号:15590821
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
-
财政年份:2003
-
负责人:KIMURA Hiroshi
-
依托单位:
Regulation of gene expression and chromatin dynamics in living cells
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批准号:15370073
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.92万
-
财政年份:2003
-
负责人:KIMURA Hiroshi
-
依托单位:
Pathogenesis on reactivation of viral infections in immunocompromised hosts and its prophylaxis and therapy.
-
批准号:13670793
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:2001
-
负责人:KIMURA Hiroshi
-
依托单位:
Assessment using hydra of endocrine disruptors contaminated in freshwater environment
-
批准号:13680623
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:2001
-
负责人:KIMURA Hiroshi
-
依托单位:
海外基金