课题基金 / 基金详情

Cell therapy against intractable EB virus infection using immunological tolerance

Cell therapy against intractable EB virus infection using immunological tolerance
利用免疫耐受的细胞疗法对抗顽固性 EB 病毒感染
批准号:
24659493
负责人:
KIMURA Hiroshi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

项目摘要

项目成果

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中文摘要
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英文摘要
Severe Epstein-Barr virus (EBV) infections, such as chronic active EBV infection and EBV-associated hemophagocytic lymphohistiocytosis, are refractory to therapies and intractable diseases. Recently, fetal-maternal lymphohematopoietic microchimerism can be detected in blood from healthy individuals, and immunological tolerance exists between mothers and children. In this study, in order to develop novel therapies for severe EBV infections, fundamental studies including the proof of fetomaternal microchimerism have been performed for establishing cell therapy.
期刊论文(25)
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科研奖励(0)
会议论文
難治性EBウイルス感染症~EBV-HLHとCAEBVの病態から治療まで~ : CAEBV~アジア型と欧米型~
难治性EB病毒感染~从EBV-HLH和CAEBV的病理到治疗~:CAEBV~亚洲型和西方型~
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kawada JI, Ito Y, Iwata S, Kawano Y, Kanazawa T, Siddiquey MN, and Kimura H., 木村宏, 木村宏]
通讯作者: 木村宏
A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation
同种异体外周血干细胞移植后EB病毒感染的自然杀伤细胞的单克隆扩增
DOI: 10.1016/j.jcv.2012.11.004
发表时间: 2013
期刊: J Clin Virol
影响因子: 8.8
作者: [Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N]
通讯作者: Komatsu N
Interleukin-17A-Producing T Lymphocytes in Chronic Active Epstein-Barr Virus Infection.
慢性活动性 Epstein-Barr 病毒感染中产生白细胞介素 17A 的 T 淋巴细胞。
DOI: 10.1111/1348-0421.12010
发表时间: 2013
期刊: Microbiology and Immunology
影响因子: 2.6
作者: [Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N., Ohta R]
通讯作者: Ohta R
ウイルス学の基礎よりみた臓器移植後の感染症
从病毒学基础看器官移植后的传染病
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kawada JI, Ito Y, Iwata S, Kawano Y, Kanazawa T, Siddiquey MN, and Kimura H., 木村宏, 木村宏, 木村宏, 木村宏, 木村宏]
通讯作者: 木村宏
14
    An on-chip hepatic metabolism model for pharmacokinetic studies
    • 批准号:
      24710141
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.91万
    • 财政年份:
      2012
    • 负责人:
      KIMURA Hiroshi
    • 依托单位:
    The decreases in hypoxic ventilatory response affect acute exacerbation in patients with respiratory failure and/or obesity hypoventilation syndrome
    • 批准号:
      23591158
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2011
    • 负责人:
      KIMURA Hiroshi
    • 依托单位:
    Live cell imaging of histone methylation and inactive X chromosome dynamics
    • 批准号:
      22370063
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.9万
    • 财政年份:
      2010
    • 负责人:
      KIMURA Hiroshi
    • 依托单位:
    Integrated "Body on a Chip" system for cell-based assay
    • 批准号:
      22710120
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
      KIMURA Hiroshi
    • 依托单位:
    海外基金