Diagnosis and pathogenetic analysis using a novel identification method for EBV-infected cells
Diagnosis and pathogenetic analysis using a novel identification method for EBV-infected cells
批准号:
21591384
负责人:
KIMURA Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
To diagnose Epstein Barr virus(EBV)-associated diseases and to explore the pathogenesis of EBV infection, not only must the EBV load be measured, but EBV-infected cells must also be identified. We established a novel flow cytometric in situ hybridization assay to detect EBER and surface antigen in EBV-infected cells using an EBV-encoded small RNA(EBER) specific peptide nucleic acid probe, and showed that this assay was useful for the diagnosis and decision of treatment against EBV-associated T/NK lymphoproliferative diseases such as chronic active EBV infection or post transplant lymphoproliferative disorders.
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Kinetics of Epstein-Barr Virus Load and Virus-Specific CD8+ T Cells in Acute Infectious Mononucleosis.
急性传染性单核细胞增多症中 Epstein-Barr 病毒载量和病毒特异性 CD8 T 细胞的动力学。
DOI:
--
发表时间:
2010
期刊:
J Clin Virol
影响因子:
8.8
作者:
[Hoshino Y, Nishikawa K, Ito Y, et al.]
通讯作者:
et al.
Multiplex real-time PCR for the simultaneous detection of her pes simplex virus
多重实时 PCR 同时检测单纯疱疹病毒
DOI:
--
发表时间:
2009
期刊:
Microbiol Immunol
影响因子:
2.6
作者:
[Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, Nishiyama Y, Kimura H.]
通讯作者:
Kimura H.
DOI:
10.1086/605610
发表时间:
2009-10-01
期刊:
JOURNAL OF INFECTIOUS DISEASES
影响因子:
6.4
作者:
[Kimura, Hiroshi, Miyake, Kanae, Nishiyama, Yukihiro]
通讯作者:
Nishiyama, Yukihiro
DOI:
10.1111/j.1348-0421.2010.00243.x
发表时间:
2010-09-01
期刊:
MICROBIOLOGY AND IMMUNOLOGY
影响因子:
2.6
作者:
[Ito, Yoshinori, Takakura, Shunji, Kimura, Hiroshi]
通讯作者:
Kimura, Hiroshi
Immunologic and Virologic Analyses in Pediatric Liver Transplant Recipients with Chronic High Epstein-Barr Viral Loads.
慢性高 Epstein-Barr 病毒载量的儿童肝移植受者的免疫学和病毒学分析。
DOI:
--
发表时间:
2010
期刊:
J Infect Dis 202(3)
影响因子:
--
作者:
[Ito Y, Kimura H, et al]
通讯作者:
et al
共 19 条
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Science and Technology Studies to Develop the Governance for Effective Use of Nuclear Energy
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Infrared Spectra of Comets as a Barometer for Their Evolution
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The structure and dynamics of chromatin harboring specific histone modifications
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Hypoxic stress in sleep apnea causes systemic inflammation and promotes atherosclerosis.
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国内基金
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