害虫抵抗性を付与する植物免疫受容体の同定

鉴定赋予害虫抗性的植物免疫受体

• 批准号: 22KF0398
• 负责人: 白須 賢
• 金额: $ 1.41万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2023
• 资助国家: 日本
• 起止时间: 2023-03-08 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0398/
• 关键词: Plant immunity; PRR; bioinformatics; nematode; evolution; pattern-recognition; receptors

I investigated the origin and evolution of pattern-triggered immunity (PTI) in plants. As mentioned, plants perceive PAMPs via PRRs to activate PTI. The origin and evolution of PRRs and PTI-signaling components is unclear. I performed a large-scale comparative genomic analysis on PRRs and PTI-signaling components in 350 plant species. While RLPs are generally more ancient than RLKs, RLK families have expanded much more than RLP families. I also showed that multiple PTI-signaling components are ancient and most show limited expansion in the plant lineage. These results suggest that PRRs and PTI signaling network are ancient and likely to exist before emergence of land plants, which then have evolved to become more complex and immune-specific in land plants.

我研究了植物模式触发免疫（Pattern-triggered Immunity，PTI）的起源和进化。如上所述，植物通过PRR感知PAMP以激活PTI。PRR和PTI信号成分的起源和演变尚不清楚。我对350种植物的PRRs和PTI信号成分进行了大规模的比较基因组分析。虽然RLP通常比RLKs更古老，但RLK家族的扩张比RLP家族要大得多。我还表明，多个PTI信号成分是古老的，大多数显示有限的扩展在植物谱系。这些结果表明，PRRs和PTI信号网络是古老的，可能存在于陆地植物出现之前，然后在陆地植物中进化得更加复杂和免疫特异性。