害虫抵抗性を付与する植物免疫受容体の同定

我研究了植物模式触发免疫（pattern-triggered immunity， PTI）的起源和进化。如前所述，植物通过PRRs感知PAMPs来激活PTI。PRRs和pti信号成分的起源和进化尚不清楚。我对350种植物的PRRs和pti信号组分进行了大规模的比较基因组分析。虽然RLP家族通常比RLK家族更古老，但RLK家族比RLP家族扩展得更多。我还表明，多种pti信号成分是古老的，大多数在植物谱系中显示有限的扩展。这些结果表明，PRRs和PTI信号网络是古老的，可能在陆地植物出现之前就存在了，然后在陆地植物中进化得更加复杂和具有免疫特异性。

I investigated the origin and evolution of pattern-triggered immunity (PTI) in plants. As mentioned, plants perceive PAMPs via PRRs to activate PTI. The origin and evolution of PRRs and PTI-signaling components is unclear. I performed a large-scale comparative genomic analysis on PRRs and PTI-signaling components in 350 plant species. While RLPs are generally more ancient than RLKs, RLK families have expanded much more than RLP families. I also showed that multiple PTI-signaling components are ancient and most show limited expansion in the plant lineage. These results suggest that PRRs and PTI signaling network are ancient and likely to exist before emergence of land plants, which then have evolved to become more complex and immune-specific in land plants.