Electronic Cigarettes During Pregnancy: Impact on Fetal Development
怀孕期间电子烟:对胎儿发育的影响
基本信息
- 批准号:10163831
- 负责人:
- 金额:$ 62.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-15 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:1-Butanol3-Dimensional3D ultrasound4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolAddressAgeAnimalsAreaArousalAttentionBehavioralBiologicalBiological MarkersBirthBirth WeightBrainCarbon MonoxideCephalicCerebellumChildChild HealthCigaretteClinicalCohort StudiesCorpus CallosumCost efficiencyCotinineDataDevelopmentDiscipline of obstetricsDrug usageElectronic cigaretteEnvironmentExposure toFetal DevelopmentFetal GrowthFetal Neurobehavioral DevelopmentFetusGestational AgeGoalsGrowthHarm ReductionHead circumferenceHumanImageInfantInformal Social ControlInvestigationLiteratureLongevityMeasuresMethodsMothersNational Institute of Drug AbuseNeonatalNicotineOutcomePostpartum PeriodPregnancyPregnant WomenProviderPublic HealthPublishingRelative RisksReportingReproductive HealthResearchResolutionRiskRisk MarkerSamplingSeminalSmokingStrategic PlanningStructureSystemTimeTobaccoTobacco-Associated CarcinogenToxic effectUltrasonographyVaporizerWomanbasebiobehaviorbiological adaptation to stressbiomarker developmentcarcinogenicitycigarette smokingcohortcombustible cigarettecombustion productdevelopmental toxicityelectronic cigarette useelectronic cigarette userelectronic liquidfetalfrontal lobehigh risk infantimage processinginnovationmaternal cigarette smokingneurobehaviorneurobehavioralnovelpregnantprenatalprenatal exposureprospectiverecruitrelating to nervous systemsocialtobacco productstwo-dimensional
项目摘要
Project Summary/Abstract
While cigarette use has declined in the US, use of electronic cigarettes (e-cigs) has increased dramatically
since their introduction to the US in 2007. Tremendous controversy has emerged regarding their potential risks
(renormalizing smoking, dangers of e-liquids) versus potential for harm reduction (“clean” nicotine delivery sys-
tem without tobacco combustion products). The question of risks vs harm reduction is even more salient
during pregnancy due to impact of maternal use on both mother and fetus and evidence for vulnerabil-
ity of the developing fetus to both nicotine and combustion products. Recent published reports reveal
rates of e-cig use of 4-15% among pregnant women; pilot data from our group revealed doubling of prenatal e-
cig use between 2012 and 2017. Given evidence of increasing e-cig use by pregnant women, known fetal tox-
icity from nicotine, and a need for data to inform pregnant women and obstetric providers, research to deter-
mine the impact and relative impact (vs cigarettes) of e-cigs on fetal development is urgently needed.
To date, however, there are no published studies of the impact of e-cig use during pregnancy on fetal develop-
ment. We propose the first study of the impact of e-cigs during pregnancy on the developing fetus, in-
cluding markers of fetal growth and novel measures of fetal brain and neurobehavioral development.
Our group pioneered combined use of real-time ultrasound and fetal actocardiography to characterize fetal
neurobehavior. The advent of 3D ultrasound offers higher resolution fetal images and allows volumetric char-
acterization of specific fetal brain structures. Seminal preliminary data from our group highlights feasibility of
recruiting pregnant e-cig users as well as initial evidence for alterations in fetal growth, fetal fronto-cerebellar
brain structures and fetal neurobehavioral development in e-cig users. The proposed study is an intensive pro-
spective investigation of three groups of mother-fetus pairs: E-cig users, Cig users and Controls. Comprehen-
sive measures of fetal growth, neural structures, and neurobehavioral development will be assessed over preg-
nancy using 2D and 3D ultrasonography followed by neonatal ultrasound and neurobehavioral assessment.
Maternal and fetal nicotine, combustion and carcinogenicity biomarkers will also be assessed. Our goals are to
determine the impact of prenatal e-cigs on: (1) fetal growth and infant birth weight, (2) fetal/infant brain devel-
opment, (3) fetal/infant neurobehavioral development. We will also explore: (4) associations between nicotine
and toxicity biomarkers with fetal growth, brain and neurobehavioral development. The proposed study ad-
dresses an urgent and unanswered public health question. Given increasing rates of e-cig use and the exquis-
ite sensitivity of the developing fetus to disruptions in the prenatal environment, determining the risks and rela-
tive risks of e-cig use in pregnancy is timely and offers potential to impact the health of reproductive age
women and their children.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('LAURA R STROUD', 18)}}的其他基金
COBRE for Stress, Trauma and Resilience (STAR)
COBRE 压力、创伤和复原力 (STAR)
- 批准号:
10686037 - 财政年份:2021
- 资助金额:
$ 62.6万 - 项目类别:
COBRE for Stress, Trauma and Resilience (STAR)
COBRE 压力、创伤和复原力 (STAR)
- 批准号:
10090775 - 财政年份:2021
- 资助金额:
$ 62.6万 - 项目类别:
COBRE for Stress, Trauma and Resilience (STAR)
COBRE 压力、创伤和复原力 (STAR)
- 批准号:
10478808 - 财政年份:2021
- 资助金额:
$ 62.6万 - 项目类别:
Research Training in Childhood Stress, Trauma, and Resilience
童年压力、创伤和复原力的研究培训
- 批准号:
10617795 - 财政年份:2020
- 资助金额:
$ 62.6万 - 项目类别:
Research Training in Childhood Stress, Trauma, and Resilience
童年压力、创伤和复原力的研究培训
- 批准号:
10405076 - 财政年份:2020
- 资助金额:
$ 62.6万 - 项目类别:
Electronic Cigarettes During Pregnancy: Impact on Fetal Development
怀孕期间电子烟:对胎儿发育的影响
- 批准号:
9755393 - 财政年份:2018
- 资助金额:
$ 62.6万 - 项目类别:
Electronic Cigarettes During Pregnancy: Impact on Fetal Development
怀孕期间电子烟:对胎儿发育的影响
- 批准号:
10403818 - 财政年份:2018
- 资助金额:
$ 62.6万 - 项目类别:
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