COBRE for Stress, Trauma and Resilience (STAR)

COBRE 压力、创伤和复原力 (STAR)

• 批准号: 10686037
• 负责人: LAURA R STROUD
• 金额: $ 220.37万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686037
• 关键词: Address; Adult; Adverse event; Affective; American; Behavioral; Behavioral Mechanisms; Biological; Biological Markers; Cardiovascular Diseases; Centers of Research Excellence; Child; Child Abuse and Neglect; Child Sexual Abuse; Childhood; Chronic Obstructive Pulmonary Disease; Communities; Data; Development; Diet; Dimensions; Disease; Doctor of Philosophy; Documentation; Education; Ethics; Evaluation; Exposure to; Faculty; Faculty Recruitment; Funding; Goals; Health; Hospitals; Hypertension; Inflammatory; Infrastructure; Intervention; Laboratories; Lead; Leadership; Life Cycle Stages; Link; Longevity; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Mentors; Mentorship; Metabolic; Methods; Minority Groups; Obesity; Outcome; Phase; Pilot Projects; Population Heterogeneity; Poverty; Pregnancy; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Risk; Sampling; Science; Scientist; Strategic Planning; Stress; Symptoms; Teacher Professional Development; Technology; Time; Training; Trauma; Trauma Research; Underrepresented Minority; United States National Institutes of Health; Vulnerable Populations; Weight Gain; adverse childhood events; career; childhood adversity; community partnership; data management; deprivation; early childhood; early life adversity; early-career faculty; emotion regulation; ethnic minority; executive function; experience; experimental study; faculty mentor; food insecurity; human subject; improved; in vivo; innovation; maltreatment; multidisciplinary; neglect; next generation; novel; pediatric trauma; perinatal outcomes; physical conditioning; poor health outcome; pregnancy disorder; programs; racial minority; recruit; resilience; resilience research; statistics; stress reactivity; stressor; substance use; young adult

PROJECT SUMMARY / ABSTRACT There is increasing evidence for a profound and persistent impact of childhood stress and trauma on psychological and physical health outcomes over the lifespan. The strength and consistency of these associations has led to a paradigm shift in approaching adult disease in which addressing the early childhood origins of health and disease is considered to be equal to if not more critical than intervention efforts with adults. However, despite the magnitude of risk associated with adverse childhood experiences, there is limited understanding of the precise mechanisms by which early adversity impacts health. We propose to establish a Phase I Center of Biomedical Research Excellence (COBRE) for Stress, Trauma, and Resilience (STAR) at The Miriam Hospital to address this critical gap. The STAR COBRE is unified by a conceptual framework focused on (a) isolating/disentangling specific stress exposures and traumas, and (b) identifying proximal mechanisms of risk and resilience with in-vivo ecological sampling that will lead rapidly to novel and actionable intervention targets to improve health. The COBRE incorporates a life course approach, with an emphasis on sensitive periods of development—pregnancy, childhood, and young adulthood. Three promising, early career Project Leaders, a junior faculty recruit with expertise in STAR from an under-represented minority group, and a diversity-focused pilot project program funded by The Miriam Hospital form the nexus of the STAR CO- BRE. Co-mentorship by two leading NIH-funded scientists with complementary expertise will catalyze the transition of the Project Leaders to independent funding. Dr. Bublitz will utilize cutting-edge ecological methods to understand links between maternal history of childhood sexual abuse and hypertensive disorders of pregnancy. Dr. Evans will conduct a naturalistic experiment in children to elucidate the specific impact of food insecurity from other poverty-related stressors on diet, inflammatory and metabolic biomarkers and summer weight gain; Dr. Vergara-Lopez will utilize a novel dimensional approach to childhood maltreatment to contrast the impact of deprivation (neglect) vs. threat (abuse) on young adult emotion regulation strategies and mental health symptoms. To support Project Leaders and the STAR COBRE, we will establish an Administrative Core, including a community advisory board and a state-of-the art Mentoring and Education program, and two research cores: the Technology, Assessment, Data, and Analysis (TADA) Core will support methods harnessing cutting-edge technology, data management and statistics; the Human Subjects and Vulnerable Populations (VP) Core will support recruitment/retention of vulnerable and diverse populations and community partnerships. The STAR COBRE will serve as the only research center in Rhode Island focused on stress, trauma, and resilience. Our long-term goal is to develop and sustain a critical mass of investigators to establish The Miriam Hospital as a vibrant regional and national hub for transformative research into mechanisms of risk and resilience following childhood exposure to stress, trauma, and adversity.

项目概要/摘要 越来越多的证据表明，童年压力和创伤对一生中的心理和身体健康结果产生深远而持久的影响。这些协会的实力和一致性 导致了处理成人疾病的范式转变，其中解决了儿童早期健康的根源 疾病被认为与成人的干预措施同等重要，甚至更重要。然而，尽管与不良童年经历相关的风险很大，但人们对 早期逆境影响健康的确切机制。我们建议建立一期中心 米里亚姆压力、创伤和复原力 (STAR) 生物医学卓越研究 (COBRE) 医院要解决这一关键差距。 STAR COBRE 由一个概念框架统一起来，重点关注 (a) 隔离/解开特定的压力暴露和创伤，以及（b）确定最近的机制 体内生态采样的风险和恢复力将迅速产生新颖且可操作的干预目标，以改善健康。 COBRE 纳入了生命历程方法，重点是 发育的敏感时期——怀孕期、儿童期和成年早期。三位有前途的早期职业项目负责人，一位来自代表性不足的少数群体的具有 STAR 专业知识的初级教员， 以及由 Miriam 医院资助的以多元化为重点的试点项目计划构成了 STAR CO- 布雷。由 NIH 资助的两位具有互补专业知识的领先科学家共同指导将促进项目负责人向独立资助的过渡。 Bublitz 博士将利用尖端的生态方法 了解母亲童年性虐待史与妊娠期高血压疾病之间的联系。埃文斯博士将对儿童进行一项自然主义实验，以阐明其他与贫困相关的压力因素导致的粮食不安全对饮食、炎症和代谢生物标志物以及夏季的具体影响。 体重增加；维加拉-洛佩兹博士将利用一种新颖的维度方法来处理儿童虐待问题 剥夺（忽视）与威胁（虐待）对年轻人情绪调节策略和心理的影响 健康症状。为了支持项目领导者和 STAR COBRE，我们将建立一个行政核心， 包括一个社区咨询委员会和一个最先进的指导和教育计划，以及两个 研究核心：技术、评估、数据和分析（TADA）核心将支持利用尖端技术、数据管理和统计的方法；人类受试者和弱势群体（VP）核心将支持招募/保留弱势和多样化群体和社区 伙伴关系。 STAR COBRE 将成为罗德岛州唯一一个专注于 压力、创伤和复原力。我们的长期目标是培养和维持足够数量的研究人员，以 将米里亚姆医院建成一个充满活力的地区和国家中心，对儿童遭受压力、创伤和逆境后的风险和复原力机制进行变革性研究。

项目成果

Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate.

• DOI: 10.3390/genes14081576
• 发表时间: 2023-08-02
• 期刊: GENES
• 影响因子: 3.5
• 作者: Chitwood, Dylan G.;Uy, Lisa;Fu, Wanfang;Klaubert, Stephanie R.;Harcum, Sarah W.;Saski, Christopher A.
• 通讯作者: Saski, Christopher A.

Tsc2 coordinates neuroprogenitor differentiation.

• DOI: 10.1016/j.isci.2023.108442
• 发表时间: 2023-12-15
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Riley, Victoria A.;Shankar, Vijay;Holmberg, Jennie C.;Sokolov, Aidan M.;Neckles, Victoria N.;Williams, Kaitlyn;Lyman, Rachel;Mackay, Trudy F. C.;Feliciano, David M.
• 通讯作者: Feliciano, David M.

Premium and Non-Premium Cigar Use Among a Nationally Representative Sample of Reproductive Age Women: Findings from the 2010-2019 National Survey on Drug Use and Health.

• DOI: 10.1093/ntr/ntad020
• 发表时间: 2023-07-28
• 期刊: NICOTINE & TOBACCO RESEARCH
• 影响因子: 4.7
• 作者: Sharma, Eva;Gautam, Prem;Jao, Nancy C.;Stroud, Laura R.
• 通讯作者: Stroud, Laura R.

Psychological Risk Factors in Pulmonary Rehabilitation: ANXIETY, DEPRESSION, SOCIAL ISOLATION, AND COGNITIVE IMPAIRMENT.

肺康复中的心理危险因素：焦虑、抑郁、社会孤立和认知障碍。

• DOI: 10.1097/hcr.0000000000000843
• 发表时间: 2024
• 期刊: Journal of cardiopulmonary rehabilitation and prevention
• 影响因子: 3.8
• 作者: Gaffey,AllisonE;Goldstein,CarlyM;Lee,SharonY;Hays,MeganM;Gaalema,DiannE
• 通讯作者: Gaalema,DiannE

Exploring the Impact of Maternal and Paternal Acceptance on Adolescent Girls' Emotion Regulation.

探索母亲和父亲的接受度对青春期女孩情绪调节的影响。

• DOI: 10.1007/s10578-022-01405-9
• 发表时间: 2024
• 期刊: Child psychiatry and human development
• 影响因子: 2.9
• 作者: Vergara-Lopez,Chrystal;Sokol,NatashaA;Bublitz,MargaretH;Gaffey,AllisonE;Gomez,Andrea;Mercado,Nadia;Silk,JenniferS;Stroud,LauraR
• 通讯作者: Stroud,LauraR