COBRE for Stress, Trauma and Resilience (STAR)

COBRE 压力、创伤和复原力 (STAR)

• 批准号: 10478808
• 负责人: LAURA R STROUD
• 金额: $ 222.96万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478808
• 关键词: Address; Adult; Adverse event; Affective; American; Behavioral; Behavioral Mechanisms; Biological; Biological Markers; Cardiovascular Diseases; Centers of Research Excellence; Child; Child Abuse and Neglect; Child Sexual Abuse; Childhood; Chronic Obstructive Pulmonary Disease; Communities; Data Analyses; Development; Diet; Dimensions; Disease; Doctor of Philosophy; Documentation; Education; Ethics; Evaluation; Exposure to; Faculty; Faculty Recruitment; Funding; Goals; Health; Hospitals; Hypertension; Inflammatory; Infrastructure; Intervention; Laboratories; Lead; Leadership; Life Cycle Stages; Link; Longevity; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Mentors; Mentorship; Metabolic; Methods; Minority Groups; Obesity; Outcome; Phase; Pilot Projects; Population Heterogeneity; Poverty; Pregnancy; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Risk; Sampling; Science; Scientist; Strategic Planning; Stress; Symptoms; Teacher Professional Development; Technology; Technology Assessment; Time; Training; Trauma; Underrepresented Minority; United States National Institutes of Health; Vulnerable Populations; Weight Gain; abuse neglect; adverse childhood events; base; career; childhood adversity; community partnership; data management; deprivation; early childhood; early life adversity; early-career faculty; emotion regulation; ethnic minority; executive function; experience; experimental study; faculty mentor; food insecurity; human subject; improved; in vivo; innovation; maltreatment; multidisciplinary; neglect; next generation; novel; pediatric trauma; perinatal outcomes; physical conditioning; pregnancy disorder; programs; racial and ethnic; recruit; resilience; statistics; stress reactivity; stressor; substance use; young adult

PROJECT SUMMARY / ABSTRACT There is increasing evidence for a profound and persistent impact of childhood stress and trauma on psychological and physical health outcomes over the lifespan. The strength and consistency of these associations has led to a paradigm shift in approaching adult disease in which addressing the early childhood origins of health and disease is considered to be equal to if not more critical than intervention efforts with adults. However, despite the magnitude of risk associated with adverse childhood experiences, there is limited understanding of the precise mechanisms by which early adversity impacts health. We propose to establish a Phase I Center of Biomedical Research Excellence (COBRE) for Stress, Trauma, and Resilience (STAR) at The Miriam Hospital to address this critical gap. The STAR COBRE is unified by a conceptual framework focused on (a) isolating/disentangling specific stress exposures and traumas, and (b) identifying proximal mechanisms of risk and resilience with in-vivo ecological sampling that will lead rapidly to novel and actionable intervention targets to improve health. The COBRE incorporates a life course approach, with an emphasis on sensitive periods of development—pregnancy, childhood, and young adulthood. Three promising, early career Project Leaders, a junior faculty recruit with expertise in STAR from an under-represented minority group, and a diversity-focused pilot project program funded by The Miriam Hospital form the nexus of the STAR CO- BRE. Co-mentorship by two leading NIH-funded scientists with complementary expertise will catalyze the transition of the Project Leaders to independent funding. Dr. Bublitz will utilize cutting-edge ecological methods to understand links between maternal history of childhood sexual abuse and hypertensive disorders of pregnancy. Dr. Evans will conduct a naturalistic experiment in children to elucidate the specific impact of food insecurity from other poverty-related stressors on diet, inflammatory and metabolic biomarkers and summer weight gain; Dr. Vergara-Lopez will utilize a novel dimensional approach to childhood maltreatment to contrast the impact of deprivation (neglect) vs. threat (abuse) on young adult emotion regulation strategies and mental health symptoms. To support Project Leaders and the STAR COBRE, we will establish an Administrative Core, including a community advisory board and a state-of-the art Mentoring and Education program, and two research cores: the Technology, Assessment, Data, and Analysis (TADA) Core will support methods harnessing cutting-edge technology, data management and statistics; the Human Subjects and Vulnerable Populations (VP) Core will support recruitment/retention of vulnerable and diverse populations and community partnerships. The STAR COBRE will serve as the only research center in Rhode Island focused on stress, trauma, and resilience. Our long-term goal is to develop and sustain a critical mass of investigators to establish The Miriam Hospital as a vibrant regional and national hub for transformative research into mechanisms of risk and resilience following childhood exposure to stress, trauma, and adversity.

项目摘要/摘要 越来越多的证据表明，童年压力和创伤对一生中的心理和身体健康结果具有深远和持久的影响。这些联系的力量和一致性已经 导致了处理成人疾病的范式转变，其中解决了儿童早期健康的起源 疾病被认为与成人的干预努力同等重要，如果不是更严重的话。然而，尽管与不良童年经历相关的风险很大，但对 早期逆境影响健康的确切机制。我们建议建立一期中心 MIRiam的压力、创伤和恢复力生物医学研究杰出奖(COBRE) 医院来解决这一关键差距。明星眼镜蛇由一个概念框架统一起来，重点放在(A) 隔离/解开特定的应激暴露和创伤，以及(B)确定 风险和复原力与体内生态采样，这将迅速导致新的和可操作的干预目标，以改善健康。Cobre采用了生命过程方法，重点是 发育敏感期--孕期、儿童期和青壮年。三位有前途的早期职业项目负责人，一名初级教职员工，从代表不足的少数族裔群体中招募了具有STAR专业知识的人， 由Miriam医院资助的专注于多样性的试点项目形成了STAR CO- 布雷。由两位由美国国立卫生研究院资助的具有互补专业知识的领先科学家共同指导，将促进项目负责人向独立资助的过渡。Bublitz博士将利用尖端的生态学方法 了解儿童期性虐待母亲病史与妊娠高血压疾病之间的联系。埃文斯博士将在儿童中进行一项自然主义实验，以阐明来自其他贫困相关应激源的食物不安全对饮食、炎症和代谢生物标记物以及夏季的具体影响。 体重增加；Vergara-Lopez博士将利用一种新的维度方法来对比童年虐待 剥夺(忽视)与威胁(虐待)对青少年情绪调节策略和心理的影响 健康症状。为了支持项目负责人和明星眼镜蛇，我们将建立一个行政核心， 包括一个社区咨询委员会和一个最先进的辅导和教育计划，以及两个 研究核心：技术、评估、数据和分析(TADA)核心将支持利用尖端技术、数据管理和统计的方法；人类主体和弱势群体(VP)核心将支持招募/留住弱势和多样化人口和社区 合伙企业。明星科布雷将作为罗德岛唯一一个专注于 压力、创伤和韧性。我们的长期目标是培养和维持一批足够多的调查人员 将Miriam医院建立为一个充满活力的区域和国家中心，用于对儿童暴露于压力、创伤和逆境后的风险和弹性机制进行变革性研究。