Core-005

洛克菲勒临床与转化科学中心（CCTS）的总体目标是加速 转化研究，以改善人类健康和培训劳动力，包括新的临床和转化 研究人员，在方法，知识和实践，以最好地进行翻译研究。Hub研究 核心能力通过将特殊人群纳入研究， 提供参与者和临床互动，以加速转化研究。核心的具体目标是： 1.鼓励特殊人群（包括儿童、老年病人、 以前致命的儿童疾病，少数民族，和服务不足或健康差距的人口，包括种族， 种族或性别差异以及社会经济地位、城市环境、孕妇、 残疾人和其他“难以接触”的群体）的研究，方法是：a）提供全面的 新的翻译研究导航（TRN）计划中的服务，以协助研究人员参与 人群并招募他们参与研究，B）与临床主任网络（CDN）合作， 基于研究网络，服务于不同的患者人群，c）与其他CTSA中心合作， 纽约市临床数据研究网络（NYC-CDRN）中的CDN，以建立这个重要的数据库， 来自特殊人群的潜在参与者，d）与位于斯克里普斯范德比尔特的CTSA中心合作， 爱因斯坦，纽约大学，哥伦比亚和威尔康奈尔大学的一系列倡议，正在开发新的方法， 吸引特殊人群。2.通过以下方式加强参与者和临床互动：a）启动 创新的多学科转化研究导航计划，以加快发展， 转化研究，并增加科学家和临床医生获得所需的监管 知识、科学合理的研究设计、适当的方法和所需的临床研究人员 B）提供全系统的监督和监测， 确保研究过程的最大完整性和参与者的安全，c）使用指标来评估成功 对协议的制定、实施、进展和完成进行评估，并推动绩效改进。 我们将通过教育研究人员了解整合特殊功能的好处来实现第一个具体目标。 研究人员将他们的研究范围扩大到整个年龄范围。我们还将协助 他们直接识别特殊人群，并通过我们与CDN的合作，因为联邦政府 CDN的合格健康中心成员为种族和民族多样化的个人群体提供服务， 其中许多人来自医疗服务不足的人群。我们将通过以下方式实现第二个具体目标 提供全面的翻译研究导航计划，将知识专家结合在一起， 一系列研究元素，包括基础设施系统和信息平台，以加快协议 制定和实施药物临床试验质量管理规范（GCP）标准。

The overall goal of the Rockefeller Center for Clinical and Translational Science (CCTS) is to accelerate translational research to improve human health and to train a workforce, including new clinical and translational investigators, in methods, knowledge, and practices to best perform translational research. The Hub Research Capacity Core contributes to these goals by integrating special populations into research studies and providing participant and clinical interactions to accelerate translational research. The Core’s specific aims are: 1. To encourage the Integration of Special Populations (including children, older patients, survivors of formerly lethal childhood diseases, minority, and underserved or health disparity populations including racial, ethnic or gender differences as well as socio-economic status, urban environment, pregnant women, people with disability and other “hard-to-reach” groups) in research by: a) providing a comprehensive range of services in the new Translational Research Navigation (TRN) program to assist investigators in engaging populations and recruiting them to studies, b) collaborating with Clinical Directors Network (CDN), a Practice Based Research Network that serves a diverse patient population, c) collaborating with other CTSA hubs and CDN in the NYC Clinical Data Research Network (NYC-CDRN) to build this vital database for identifying potential participants from special populations, d) collaborating with the CTSA hubs at Vanderbilt, Scripps, Einstein, NYU, Columbia, and Weill Cornell on a series of initiatives that are developing novel methods for engaging special populations. 2. To enhance Participant and Clinical Interactions by: a) Initiating the innovative multi-disciplinary Translational Research Navigation program to accelerate the development of translational research studies and to increase access of scientists and clinicians to required regulatory knowledge, scientifically sound study designs, appropriate methods, and needed clinical research personnel and facilities throughout the “lifespan” of a clinical study, b) Providing system-wide oversight and monitoring to ensure maximal integrity of research processes and participant safety, c) Using metrics to assess the success of protocol development, implementation, progress and completion, and to drive performance improvement. We will accomplish the first specific aim by educating investigators about the benefits of integrating special populations into their studies and extending their research across the entire age spectrum. We will also assist them in identifying special populations directly and via our collaboration with CDN, since the Federally Qualified Health Center members of CDN serve a racially and ethnically diverse population of individuals, many of whom are from medically underserved populations. We will accomplish the second specific aim by providing a comprehensive Translational Research Navigation program that combines knowledge experts in a range of research elements with infrastructure systems and informatics platforms to speed protocol development and implementation of the standards of Good Clinical Practice (GCP).