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Core Grant for Vision Research

视觉研究核心资助

基本信息

批准号：
10216267
负责人：
W MATTHEW PETROLL
金额：
$ 64.8万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10216267
关键词：
Adenoviruses Area Award Basic Science Biometry Cell Culture Techniques Cell Line Cells Center Core Grants Collaborations Complex Contract Services Core Facility Core Grant DNA Data Analyses Development Environment Equipment Experimental Designs Faculty Foundations Funding Goals Institution Lentivirus Maintenance Medical Students Medical center Molecular Biology Ophthalmology Outcome Phenotype Postdoctoral Fellow Privatization Production Productivity Publications Reproducibility Research Research Activity Research Personnel Research Project Grants Resources Scientist Services Structure Techniques Time Tissues Training Universities Validation Virus Vision Vision research Work cellular imaging cost effective design digital imaging equipment training experience experimental analysis graduate student improved member microscopic imaging novel operation programs quantitative imaging ranpirnase recruit research study vision development vision science

项目摘要

Abstract: The overall goal of this NEI Core Center Grant for Vision Research is to enhance the capabilities of vision research scientists by facilitating easy access to equipment, training and technical support which will expand experimental capabilities, result in more cost-effective and time-efficient research, and open up new research directions. This Center will serve vision science researchers across the UT Southwestern Medical Center (UTSW) campus. It will also facilitate new research collaborations and utilization of the core facilities by vision scientists at other nearby institutions. Our proposed NEI Core Center consists of three Resource/Service Modules, each directed by a faculty member with experience and expertise in their unit’s focus area: 1) Cell Culture and Cell Phenotyping (Directed by Dr. Danielle Robertson), which will support the maintenance and authentication of cell lines that are required for rigorous study across a wide range of research activities, and provide equipment and support for quantitative cellular analysis applications; 2) Molecular Biology/Virus Production (Directed by Dr. John Hulleman), which will provide full service DNA production and validation as well as lentivirus and adenovirus production and purification; and, 3) Microscopy and Digital Imaging (Directed by Dr. Matthew Petroll), which will provide equipment, infra-structural support, supplies and technical assistance for quantitative imaging of cells and tissues. In addition, the Center includes a biostatistician who will work with Investigators on the design of their research studies, rigorous analysis of their data, and interpretation of their results. The Specific Aims of the Core Center are to enhance, streamline and add scientific rigor to the research activities of the participating vision scientists by: 1) Supporting the operation of the Resource/Service Modules by managing usage and operations, and providing for skilled technical assistance, equipment maintenance, and the purchase of supplies; 2) providing biostatistical services to Core investigators for the design and analysis of their research studies; 3) expanding the number of collaborative research projects between investigators both within UTSW and between UTSW and other neighboring institutions; 4) creating a more fertile environment for the development of vision research programs of junior faculty members, and for new vision researchers recruited into the University; and, 5) providing resources and training to assist graduate students, medical students, and post-doctoral fellows with their research. Overall, we anticipate that the Core Grant for Vision Research will impact the research programs of these researchers by allowing them to: 1) expand into new research areas through the addition of novel experimental techniques; 2) develop new collaborations with other Core Center users throughout the region; 3) improve their productivity and efficiency through the use of Core services; and, 4) optimize their experimental design and analysis to maintain a high level of rigor and reproducibility.

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