Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function

科罗拉多州性别差异和妇女健康卓越专业研究中心(SCORE) 侧重于性腺功能丧失的生物能量和心脏新陈代谢后果。这个 该评分的首要科学目标是解决性腺老化对 通过机械驱动的研究来调节能量动态平衡和新陈代谢 从基础到临床的翻译光谱。科学的前提是性腺衰老，通过 伴随着性激素的下降，会导致生物变化，从而增加患慢性病的风险。 重要的是，因为性腺功能衰竭在中年女性中是不可避免的，但在男性中却很少见，直到晚年， 这符合SCORE计划的目标，即研究影响妇女健康的性别差异。这个 科罗拉多州的评分集中在腹部脂肪堆积的增加倾向和相关的 由于卵巢功能丧失而导致的心脏代谢功能障碍。最重要的教育 目标是让新的研究人员参与到与分数焦点一致的研究中。比分将会 提供有指导的职业发展和培训，指导如何进行适当解决以下问题的研究 性别作为生物变量(SABV)。这些总体目标将通过以下方式实现 目标：1)推进对假设有助于 腹部肥胖和心脏代谢性功能障碍，在雌二醇停用后加速。所有项目 将重点放在犬尿氨酸途径上，因为有新的证据表明它调节能量 动态平衡、代谢功能和衰老过程。科罗拉多州得分调查人员是 这些领域，并处于非常有利的地位，以推动这项研究。2)吸引和扶持优秀人才 具有与分数相关的研究兴趣的早期职业调查人员，并让他们参与CEC培训 这些活动将成功地推进他们的职业生涯。该分数将支持1名学者和4名飞行员 每年的项目获奖者。3)为SCORE研究项目、学者、 和试点获奖者，包括生物统计、数据管理、财务监督和 行政支持。4)与CU-AMC的其他项目合作并利用这些资源 (多学科老龄化中心、路德曼妇女健康研究中心、营养性肥胖研究 临床和翻译科学研究所中心)，以提高知名度和多学科覆盖范围 妇女健康研究和调查SABV的重要性。活动将以科学和非科学为目标 地方、地区和国家层面的社区。实现这些目标将把分数定位为 全国妇女健康研究领先者，CEC作为培训下一代的模范项目 一代科学家将SABV纳入他们的研究，目标是改善妇女的健康。

The Colorado Specialized Center of Research Excellence (SCORE) on Sex Differences and Women’s Health is focused on Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function. The overarching scientific goal of the SCORE is to address gaps in knowledge of the impact of gonadal aging on the regulation of energy homeostasis and metabolism by conducting mechanistically driven research across the basic-to-clinical translational spectrum. The scientific premise is that gonadal aging, through the accompanying decline in sex hormones, mediates biological changes that increase risk for chronic disease. Importantly, because gonadal failure is inevitable in women in mid-life, but rare in men until much later in life, this meets the objective of the SCORE Program to study sex differences that impact women’s health. The Colorado SCORE is focused on the increased propensity for abdominal fat accumulation and the associated cardiometabolic dysfunction that are consequent to the loss of ovarian function. The overarching educational objective is to engage new investigators in research aligned with the focus of the SCORE. The SCORE will provide mentored career development and training on how to conduct research that appropriately addresses sex as a biological variable (SABV). These overarching objectives will be accomplished through the following Aims: 1) Advance novel translational research on mechanisms that are postulated to contribute to the abdominal adiposity and cardiometabolic dysfunction that accelerate following estradiol withdrawal. All projects include a focus on the kynurenine pathway because of the emerging evidence that it regulates energy homeostasis, metabolic function, and the aging process. The Colorado SCORE investigators are experts in these areas and are exceptionally well positioned to advance this research. 2) Attract and support outstanding early career investigators with research interests related to the SCORE and engage them in CEC training activities that will successfully advance their careers. The SCORE will support one Scholar and four Pilot Project Awardees each year. 3) Provide infrastructural support for the SCORE Research Projects, Scholars, and Pilot Awardees through the LAC, including biostatistics, data management, financial oversight, and administrative support. 4) Partner with and leverage resources provided by other programs at CU-AMC (Multidisciplinary Center on Aging, Ludeman Center for Women’s Health Research, Nutrition Obesity Research Center, Clinical and Translational Sciences Institute) to elevate the visibility and multi-disciplinary reach of women’s health research and the importance of investigating SABV. Activities will target both scientific and lay communities at local, regional, and national levels. Achieving these Aims will position the SCORE as a national leader in women’s health research, and the CEC as a model program for training the next generation of scientists to integrate SABV in their research with a goal of improving women’s health.