Diabetes Clinical and Translational Core

糖尿病临床和转化核心

• 批准号: 10407866
• 负责人: MANISHA DESAI
• 金额: $ 17.87万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10407866
• 关键词: Abbreviations; Address; Animals; Award; Awareness; Basic Science; Biological Assay; Biomedical Research; California; Caring; Cells; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Trials; Clinical and Translational Science Awards; Collection; Communication; Computer software; Computerized Medical Record; Consent; Data; Data Analyses; Data Collection; Data Management Resources; Data Set; Diabetes Mellitus; Diabetes prevention; Diagnosis; Disease; Disincentive; Education; Evolution; Failure; Fostering; Generations; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Goals; Growth; Healthcare; Human; Immunologic Monitoring; In Vitro; Institutes; Institution; Institutional Review Boards; Insulin-Dependent Diabetes Mellitus; Interdisciplinary Study; International; Knowledge; Laboratories; Link; Manuscripts; Medicine; Metabolic; Methodology; Methods; Mission; Modernization; Non-Insulin-Dependent Diabetes Mellitus; Organ Procurements; Pediatric Hospitals; Phenotype; Procedures; Process; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Sampling; Science; Scientist; Services; Standardization; Strategic Planning; Support System; System; Technology; Testing; Tissue Sample; Training; Translating; Translational Research; United States Food and Drug Administration; Universities; Work; advanced analytics; analytical tool; base; biobank; clinical center; data access; data integrity; data management; database design; design; electronic data; empowered; human subject; human tissue; improved; innovation; interdisciplinary collaboration; islet; medical schools; member; novel; programs; prospective; sample collection; time use

DIABETES CLINICAL AND TRANSLATIONAL CORE (DCTC): PROJECT SUMMARY/ABSTRACT The goal of the Stanford Clinical & Translational Core (CTC) is to facilitate high-impact diabetes research by SDRC members. At Stanford, pioneers in cutting-edge technologies of diverse science fields are often in search of clinical collaborators with human subjects to ‘translate’ their findings to the clinic. Similarly, clinical investigators often fail to innovate based on a lack of awareness or accessibility to improved or novel methodologies. In addition, teams of scientists and clinicians attempting to translate their work often encounter hurdles with regulatory processes, sample management, and thoughtful data collection, or analysis empowered by modern analysis, leading to inefficient use of time, sample loss, failure to complete studies, and disincentive to provide banked samples for collaborators. The CTC addresses these specific needs by leveraging existing Stanford resources to focus on diabetes-specific research, thus enhancing our institution’s ability to perform innovative high-impact interdisciplinary studies that surpass the capabilities of a single investigator/laboratory. The CTC team is led by directors that are national leaders in their fields of diabetes- related research, and provides three core services: 1) Advanced support in analytics including study design, database design with setup of data capture, and linkage to the electronic medical record and biorepository, data management, and data analysis, and 2) A Bio-repository - unique at Stanford - of prospectively collected human tissue samples with standardization of collection and sample tracking, and links to clinical data, all accessible via a centralized hub. 3) The CTC will orient SDRC investigators and their teams and train them to use each of these core services effectively. In addition, the CTC is well-integrated with the Clinical Trials Research Unit (CTRU) of the Stanford CTSA-supported “SPECTRUM” programs for clinical and translational research. This integration improves efficient clinical sample collection and clinical assays for designing studies, recording data, logging samples, and linking sample results to phenotypic and metabolic data. Thus, institution- wide support exists for collaborative and “team” science, for modernizing data collection methods, and for resource sharing. The CTC will continue to leverage expertise in scientific methods and research-support systems developed on campus but that are underused or not yet tailored to diabetes research. Use of the CTC by SDRC members will advance the planning, execution and communication of coordinated, collaborative, and transformative clinical and translational research. The CTC will also serve new SDRC members at the Universities of California at Berkeley or at Davis, including those supported through the proposed Regional Pilot & Feasibility Award expansion. Based on growth of the SDRC membership, evolution of exciting new services like the CTC Bio-repository and increasing membership demand for human tissue and cell studies, we anticipate growth in use of the specialized and unique CTC services in the coming years.

糖尿病临床和翻译核心（DCTC）：项目总结/摘要 斯坦福大学临床与转化核心（CTC）的目标是通过以下方式促进高影响力的糖尿病研究： SDRC成员。在斯坦福大学，不同科学领域尖端技术的先驱们经常在 搜索与人类受试者的临床合作者，以将他们的发现“翻译”到临床。同样，临床 调查人员往往未能创新的基础上缺乏认识或可访问性，以改善或新颖的 方法论。此外，科学家和临床医生团队试图翻译他们的工作经常遇到 监管流程、样本管理和周到的数据收集或分析方面的障碍 现代分析的力量，导致时间利用效率低下，样本丢失，无法完成研究， 抑制向合作者提供库存样本。反恐委员会通过以下方式满足这些具体需要： 利用现有的斯坦福大学资源，专注于糖尿病的具体研究，从而提高我们机构的 能够进行创新的高影响力的跨学科研究，超越了单一的能力 调查员/实验室。CTC团队由糖尿病领域的国家领导人领导- 相关研究，并提供三个核心服务：1）先进的分析支持，包括研究设计， 数据库设计，包括数据采集设置，以及与电子病历和生物储存库的链接， 数据管理和数据分析，以及2）生物储存库-斯坦福大学独有-前瞻性收集 人体组织样本的标准化收集和样本跟踪，并链接到临床数据，所有 可通过集中式集线器访问。3)反恐委员会将指导国家发展和改革委员会的调查人员及其小组，并对他们进行培训， 有效地使用这些核心服务。此外，CTC与临床试验充分整合 斯坦福大学CTSA支持的“SPECTRUM”临床和转化项目的研究单位（CTRU） research.这种整合提高了有效的临床样品收集和临床测定， 记录数据、记录样品并将样品结果与表型和代谢数据相关联。因此，机构- 广泛支持协作和“团队”科学，现代化的数据收集方法， 资源共享反恐委员会将继续利用科学方法和研究支助方面的专门知识 在校园内开发的系统，但未得到充分利用或尚未针对糖尿病研究。使用 SDRC成员的CTC将推进协调的， 协作和变革性的临床和转化研究。CTC还将为新的SDRC提供服务 成员在加州大学伯克利分校或戴维斯，包括那些通过支持 建议扩大区域试点和可行性奖。根据SDRC成员的增长， 令人兴奋的新服务，如CTC生物库和不断增加的会员需求， 在细胞研究方面，我们预计在未来几年内，专门和独特的CTC服务的使用将有所增长。