Biostatistics

项目摘要 生物统计共享资源（B-SR）人员与SCI成员在所有七个项目中合作， 支持所有阶段的研究，从人口和基础科学到转化研究再到临床试验 有效性研究。能力与SCI成员的需求相匹配，提供全方位的 生物统计学和研究设计专业知识，从标准技术到专门开发的创新方法， 加强基础、转化、临床和人口科学研究工作。自上次审查以来， 根据SCI成员的反馈，将原生物统计学和信息学共享资源分为两个部分， 2017年单独的资源（经EAB和NCI批准）：（1）B-SR和（2）生物医学信息学共享 资源（BI-SR）。虽然这两种资源继续发挥协同作用，但这种变化使人们能够更深入地关注 每个SR的个人任务新的BI-SR侧重于数据组织、策展、管理和 支持这些研究的采矿。B-SR的优势是研究设计和结果分析，重点是 统计上合理的方法。B-SR还在方案审查和监测中发挥关键作用 委员会和临床试验科学审查委员会。所有节目的成员定期使用B- SR，最大的使用来自人口科学和癌症治疗计划。B-SR 在本供资期内，参与了82份以癌症为重点的出版物，其中16份是影响力大的出版物 出版物。B-SR的年度预算为261，592美元，而CCSG的要求为149，916美元。因此 B-SR寻求CCSG资金的57%的支持。

PROJECT SUMMARY The Biostatistics Shared Resource (B-SR) personnel collaborate with SCI members in all seven programs and support all phases of research, from population and basic sciences through translational studies to clinical trials and effectiveness research. Capabilities are matched to the needs of SCI members, providing a full range of biostatistics and study design expertise, from standard techniques to innovative methods developed specifically to enhance the basic, translational, clinical, and population sciences research efforts. Since the last review and based on SCI member feedback, the former Biostatistics and Informatics Shared Resource was divided into two separate resources in 2017 (with EAB and NCI approval): (1) the B-SR and (2) the Biomedical Informatics Shared Resource (BI-SR). While the two resources continue to have synergy, the change has allowed for a deeper focus on each SR’s individual missions. The new BI-SR focuses on data organization, curation, management, and mining that supports the studies. The B-SR strengths are study design and results analysis, with emphasis on statistically sound methodology. The B-SR also plays a key role in the Protocol Review and Monitoring Committee and the Clinical Trials Scientific Review Committee. Members of all programs regularly use the B- SR, with the heaviest use coming from the Population Sciences and Cancer Therapeutics programs. The B-SR participated in 82 cancer-focused publications in the current funding period, 16 of them in high-impact publications. The annual budget of the B-SR is $261,592, yet the CCSG request is $149,916. Accordingly, the B-SR seeks 57% of its support from CCSG funds.