Diabetes Clinical and Translational Core

糖尿病临床和转化核心

• 批准号: 10669023
• 负责人: MANISHA DESAI
• 金额: $ 17.87万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669023
• 关键词: Abbreviations; Address; Animals; Award; Awareness; Basic Science; Biological Assay; Biomedical Research; California; Caring; Cells; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Trials; Clinical and Translational Science Awards; Collection; Communication; Computer software; Computerized Medical Record; Consent; Data; Data Analyses; Data Collection; Data Management Resources; Data Set; Diabetes Mellitus; Diabetes prevention; Diagnosis; Disease; Disincentive; Education; Evolution; Failure; Fostering; Generations; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Goals; Growth; Healthcare; Hospitals; Human; Immunologic Monitoring; In Vitro; Institution; Institutional Review Boards; Insulin-Dependent Diabetes Mellitus; Interdisciplinary Study; International; Knowledge; Laboratories; Link; Manuscripts; Medicine; Metabolic; Methodology; Methods; Mission; Modernization; Non-Insulin-Dependent Diabetes Mellitus; Organ Procurements; Phenotype; Procedures; Process; Productivity; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Resource Sharing; Resources; Sampling; Science; Scientist; Services; Standardization; Strategic Planning; Support System; System; Technology; Testing; Tissue Sample; Training; Translating; Translational Research; United States Food and Drug Administration; Universities; Work; advanced analytics; analytical tool; biobank; clinical center; data integrity; data management; database design; design; electronic data; empowerment; human subject; human tissue; improved; innovation; interdisciplinary collaboration; islet; medical schools; member; novel; programs; prospective; sample collection; time use

DIABETES CLINICAL AND TRANSLATIONAL CORE (DCTC): PROJECT SUMMARY/ABSTRACT The goal of the Stanford Clinical & Translational Core (CTC) is to facilitate high-impact diabetes research by SDRC members. At Stanford, pioneers in cutting-edge technologies of diverse science fields are often in search of clinical collaborators with human subjects to ‘translate’ their findings to the clinic. Similarly, clinical investigators often fail to innovate based on a lack of awareness or accessibility to improved or novel methodologies. In addition, teams of scientists and clinicians attempting to translate their work often encounter hurdles with regulatory processes, sample management, and thoughtful data collection, or analysis empowered by modern analysis, leading to inefficient use of time, sample loss, failure to complete studies, and disincentive to provide banked samples for collaborators. The CTC addresses these specific needs by leveraging existing Stanford resources to focus on diabetes-specific research, thus enhancing our institution’s ability to perform innovative high-impact interdisciplinary studies that surpass the capabilities of a single investigator/laboratory. The CTC team is led by directors that are national leaders in their fields of diabetes- related research, and provides three core services: 1) Advanced support in analytics including study design, database design with setup of data capture, and linkage to the electronic medical record and biorepository, data management, and data analysis, and 2) A Bio-repository - unique at Stanford - of prospectively collected human tissue samples with standardization of collection and sample tracking, and links to clinical data, all accessible via a centralized hub. 3) The CTC will orient SDRC investigators and their teams and train them to use each of these core services effectively. In addition, the CTC is well-integrated with the Clinical Trials Research Unit (CTRU) of the Stanford CTSA-supported “SPECTRUM” programs for clinical and translational research. This integration improves efficient clinical sample collection and clinical assays for designing studies, recording data, logging samples, and linking sample results to phenotypic and metabolic data. Thus, institution- wide support exists for collaborative and “team” science, for modernizing data collection methods, and for resource sharing. The CTC will continue to leverage expertise in scientific methods and research-support systems developed on campus but that are underused or not yet tailored to diabetes research. Use of the CTC by SDRC members will advance the planning, execution and communication of coordinated, collaborative, and transformative clinical and translational research. The CTC will also serve new SDRC members at the Universities of California at Berkeley or at Davis, including those supported through the proposed Regional Pilot & Feasibility Award expansion. Based on growth of the SDRC membership, evolution of exciting new services like the CTC Bio-repository and increasing membership demand for human tissue and cell studies, we anticipate growth in use of the specialized and unique CTC services in the coming years.

糖尿病临床和转化核心（DCTC）：项目摘要/摘要 斯坦福大学临床与转化核心（CTC）的目标是促进高影响糖尿病的研究 SDRC成员。在斯坦福大学，潜水科学领域尖端技术的先驱经常出现在 搜索具有人类受试者的临床合作者，以将其发现“转化”到诊所。同样，临床 由于缺乏对改进或新颖的意识或可及性，调查人员通常无法无效 方法。此外，试图翻译工作的科学家和临床医生的团队经常遇到 通过监管流程，样本管理和周到的数据收集或分析障碍 通过现代分析的能力，导致时间效率低下，样本损失，未能完成研究以及 不利于为合作者提供银行样本。 CTC通过 利用现有的斯坦福大学资源专注于糖尿病特定研究，从而增强了我们机构的 能够进行创新的高影响力跨学科研究，超过单一的能力 研究人员/实验室。 CTC团队由导演领导，这些导演是糖尿病领域的国家领导人 - 相关研究，并提供三个核心服务：1）分析中的高级支持，包括研究设计， 数据库设计具有数据捕获的设置，并与电子病历和生物库的链接， 数据管理和数据分析，以及2）前瞻性收集的生物叛逆者 - 独特的 人体组织样品具有收集和样品跟踪标准化的标准化，以及与临床数据的链接 可通过集中式枢纽访问。 3）CTC将与SDRC调查人员及其团队保持联系，并训练他们 有效地使用这些核心服务。此外，CTC与临床试验完善 斯坦福CTSA支持的临床和转化的“频谱”计划的研究部门（CTRU） 研究。这种整合改善了有效的临床样本收集和设计研究的临床评估， 记录数据，记录样品以及将样本结果与表型和代谢数据联系起来。那是机构 - 为协作和“团队”科学，用于现代化数据收集方法以及为 资源共享。 CTC将继续利用科学方法和研究支持方面的专业知识 在校园内开发的系统，但这些系统是针对糖尿病研究量身定制的或尚未量身定制的。使用 SDRC成员的CTC将推进协调的计划，执行和沟通， 协作，变革性的临床和翻译研究。 CTC还将为新的SDRC服务 加利福尼亚大学的伯克利大学或戴维斯大学的成员，包括通过 拟议的区域飞行员和可行性奖扩展。基于SDRC成员资格的增长 令人兴奋的新服务等新服务以及对人体组织的成员需求不断增加 细胞研究，我们预计未来几年使用专业和独特的CTC服务的使用会增长。