Diabetes Clinical and Translational Core

糖尿病临床和转化核心

• 批准号: 10669023
• 负责人: MANISHA DESAI
• 金额: $ 17.87万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669023
• 关键词: Abbreviations; Address; Animals; Award; Awareness; Basic Science; Biological Assay; Biomedical Research; California; Caring; Cells; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Trials; Clinical and Translational Science Awards; Collection; Communication; Computer software; Computerized Medical Record; Consent; Data; Data Analyses; Data Collection; Data Management Resources; Data Set; Diabetes Mellitus; Diabetes prevention; Diagnosis; Disease; Disincentive; Education; Evolution; Failure; Fostering; Generations; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Goals; Growth; Healthcare; Hospitals; Human; Immunologic Monitoring; In Vitro; Institution; Institutional Review Boards; Insulin-Dependent Diabetes Mellitus; Interdisciplinary Study; International; Knowledge; Laboratories; Link; Manuscripts; Medicine; Metabolic; Methodology; Methods; Mission; Modernization; Non-Insulin-Dependent Diabetes Mellitus; Organ Procurements; Phenotype; Procedures; Process; Productivity; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Resource Sharing; Resources; Sampling; Science; Scientist; Services; Standardization; Strategic Planning; Support System; System; Technology; Testing; Tissue Sample; Training; Translating; Translational Research; United States Food and Drug Administration; Universities; Work; advanced analytics; analytical tool; biobank; clinical center; data integrity; data management; database design; design; electronic data; empowerment; human subject; human tissue; improved; innovation; interdisciplinary collaboration; islet; medical schools; member; novel; programs; prospective; sample collection; time use

DIABETES CLINICAL AND TRANSLATIONAL CORE (DCTC): PROJECT SUMMARY/ABSTRACT The goal of the Stanford Clinical & Translational Core (CTC) is to facilitate high-impact diabetes research by SDRC members. At Stanford, pioneers in cutting-edge technologies of diverse science fields are often in search of clinical collaborators with human subjects to ‘translate’ their findings to the clinic. Similarly, clinical investigators often fail to innovate based on a lack of awareness or accessibility to improved or novel methodologies. In addition, teams of scientists and clinicians attempting to translate their work often encounter hurdles with regulatory processes, sample management, and thoughtful data collection, or analysis empowered by modern analysis, leading to inefficient use of time, sample loss, failure to complete studies, and disincentive to provide banked samples for collaborators. The CTC addresses these specific needs by leveraging existing Stanford resources to focus on diabetes-specific research, thus enhancing our institution’s ability to perform innovative high-impact interdisciplinary studies that surpass the capabilities of a single investigator/laboratory. The CTC team is led by directors that are national leaders in their fields of diabetes- related research, and provides three core services: 1) Advanced support in analytics including study design, database design with setup of data capture, and linkage to the electronic medical record and biorepository, data management, and data analysis, and 2) A Bio-repository - unique at Stanford - of prospectively collected human tissue samples with standardization of collection and sample tracking, and links to clinical data, all accessible via a centralized hub. 3) The CTC will orient SDRC investigators and their teams and train them to use each of these core services effectively. In addition, the CTC is well-integrated with the Clinical Trials Research Unit (CTRU) of the Stanford CTSA-supported “SPECTRUM” programs for clinical and translational research. This integration improves efficient clinical sample collection and clinical assays for designing studies, recording data, logging samples, and linking sample results to phenotypic and metabolic data. Thus, institution- wide support exists for collaborative and “team” science, for modernizing data collection methods, and for resource sharing. The CTC will continue to leverage expertise in scientific methods and research-support systems developed on campus but that are underused or not yet tailored to diabetes research. Use of the CTC by SDRC members will advance the planning, execution and communication of coordinated, collaborative, and transformative clinical and translational research. The CTC will also serve new SDRC members at the Universities of California at Berkeley or at Davis, including those supported through the proposed Regional Pilot & Feasibility Award expansion. Based on growth of the SDRC membership, evolution of exciting new services like the CTC Bio-repository and increasing membership demand for human tissue and cell studies, we anticipate growth in use of the specialized and unique CTC services in the coming years.

糖尿病临床和翻译核心(DCTC)：项目摘要/摘要 斯坦福临床与翻译核心(CTC)的目标是通过以下方式促进高影响力的糖尿病研究 发改委委员。在斯坦福大学，不同科学领域的尖端技术的先驱们经常在 寻找与人类受试者合作的临床合作者，将他们的发现‘转化’到临床上。同样，临床 研究人员往往因为缺乏对改进或新事物的认识或接触而未能创新 方法论。此外，试图翻译他们的工作的科学家和临床医生团队经常遇到 监管流程、样本管理和深思熟虑的数据收集或分析方面的障碍 由现代分析授权，导致时间使用效率低下、样本丢失、无法完成研究，以及 不愿为合作者提供库存样本。反恐委员会通过以下方式满足这些具体需求 利用斯坦福大学现有的资源专注于针对糖尿病的研究，从而增强我们机构的 能够进行创新的、高影响的跨学科研究，超越单一学科的能力 调查员/实验室。CTC团队由糖尿病领域的全国领导者领导- 相关研究，并提供三项核心服务：1)分析方面的高级支持，包括研究设计， 数据库设计，设置数据捕获，并链接到电子病历和生物库， 数据管理和数据分析，以及2)生物信息库--斯坦福大学独一无二的--预期收集的 人体组织样本具有标准化的采集和样本跟踪，以及与临床数据的链接，所有这些 可通过中央集线器访问。3)反恐委员会将指导国家发改委调查员及其团队，并对他们进行培训 有效使用这些核心服务中的每一个。此外，CTC与临床试验很好地结合在一起 斯坦福大学CTSA支持的临床和翻译“光谱”计划的研究单位(CTRU) 研究。这种集成改进了用于设计研究的有效的临床样本收集和临床分析， 记录数据，记录样本，并将样本结果与表型和代谢数据联系起来。因此，机构- 广泛支持协作和“团队”科学，支持数据收集方法现代化，支持 资源共享。反恐委员会将继续利用科学方法和研究支助方面的专门知识。 在校园里开发的系统，但没有得到充分利用，或者还没有为糖尿病研究量身定做。使用 CTC由发改委成员推进规划、执行和沟通协调， 协作性、变革性的临床和转化性研究。CTC还将为新的国家发改委提供服务 加州大学伯克利分校或戴维斯分校的成员，包括通过 建议扩大区域试点和可行性奖。基于发改委成员的增长，演变 令人兴奋的新服务，如CTC生物信息库和对人体组织和不断增长的会员需求 在细胞研究方面，我们预计未来几年专门和独特的CTC服务的使用将会增长。