Translational Research in AD and related Dementias (TRADD)

摘要 亚利桑那大学(UA)促进阿尔茨海默病翻译研究的培训计划 AD相关痴呆症旨在解决AD治疗中的知识和经验差距 发现和临床前转化发展。为了迎接这一挑战，美国大学翻译研究中心 广告及相关痴呆症(Tradd)培训计划被设计为基于问题的翻译学习 博士前和医学博士研究生的工作经验。与2012、2015和2018年的NIH保持一致 阿尔茨海默病研究峰会和行业目标--国家阿尔茨海默氏症项目法案 培训计划是为了填补学术研究生项目中存在的AD翻译研究的关键空白。 为了实现这一目标，亚利桑那大学贸易计划将：1)招募多个科学领域的实习生 学科；2)采用基于问题的学习方法来解决AD治疗发展中的挑战 使用新兴的工具和技术；以及3)使贸易实习生具备职业发展和领导力 在21世纪进行团队科学和管理多学科团队所需的技能。通过这件事 通过这种方法，我们确保Tradd实习生培养AD所需的深厚翻译研究专业知识 治疗发展，同时：1)培养创造性和协作性解决问题的能力 作为大型团队科学的一部分，与翻译领域的专家合作；2)获得 应用理解数据科学，特别是使用AMP-AD、M2OVE-AD和 ADNI，可以加速翻译研究，并提供获得新的治疗见解的途径；3)连接 阿尔茨海默病的基因和表型变异以及治疗靶点的多方面病因；以及4)获得必要的 专业和商业技能，以驾驭多样化的融资格局，并将发现转化为 临床环境。贸易研究员将接受职业指导和领导力发展技能的管理 21世纪的多学科团队，这是耐心激励和数据驱动的。UA行业培训 该计划将培养一支多元化、跨学科和以翻译为导向的劳动力队伍，以满足关键 创建一支能够推动治疗以预防、延迟和治疗AD和AD的员工队伍面临的挑战 相关痴呆症。

Abstract The University of Arizona (UA) Training Program to Advance Translational Research on Alzheimer's Disease and AD Related Dementias is designed to address knowledge and experience gaps in AD therapeutic discovery and preclinical translational development. To meet this challenge, the UA Translational Research in AD and related Dementias (TRADD) training program is designed as a problem based translational learning experience for predoctoral Ph.D and M.D. Ph.D fellows. In alignment with the 2012, 2015 and 2018 NIH Alzheimer’s Disease Research summits and the National Alzheimer’s Project Act, the goal of the TRADD training program is to fill critical gaps that exist for AD translational research in academic graduate programs. To achieve this goal, the University of Arizona TRADD program will: 1) recruit trainees across multiple scientific disciplines; 2) employ problem-based learning approaches to solve challenges in AD therapeutic development with emerging tools and techniques; and 3) equip TRADD trainees with career development and leadership skills necessary to conduct team science and manage multidisciplinary teams in the 21st century. Through this approach, we ensure that TRADD trainees develop deep translational research expertise necessary for AD therapeutic development, while: 1) cultivating the ability to creatively and collaboratively solve problems working with experts across the translational landscape as part of large-scale team science; 2) gaining an applied understanding of how data science, particularly using data generated by AMP-AD, M2OVE-AD and ADNI, can accelerate translational research and provide avenues to novel therapeutic insights; 3) connecting geno- and phenotypic variations and multifaceted etiology of AD to therapeutic targets; and 4) gaining essential professional and business skills to navigate a diverse funding landscape and translate discoveries into the clinical setting. TRADD fellows will receive career mentoring and leadership development skills to manage multi-disciplinary teams in the 21st century that is Patient Inspired and Data Driven. The UA TRADD training program will develop a diverse, cross-disciplinary and translationally oriented workforce to meet the critical challenge of creating a workforce capable of advancing therapeutics to prevent, delay and treat AD and AD related dementias.