CAROTID ARTERY FOLLOW UP STUDY

颈动脉随访研究

• 批准号: 2415544
• 负责人: JOHN R CROUSE
• 金额: $ 10.84万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2415544
• 关键词: angiocardioultrasonography; angiography; arteriosclerosis; atherosclerotic plaque; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; carotid artery; clinical research; coronary disorder; diagnosis design /evaluation; disease /disorder proneness /risk; gender difference; human subject; longitudinal human study; noninvasive diagnosis; pathologic process; prognosis

DESCRIPTION: (Adapted from Investigator's Abstract) This is a revised application for a competing continuation. Previous case-control and cross-sectional studies have shown an association between extracranial carotid artery intimal-medial thickening (ECIMT) and coronary artery disease (CAD). The present proposal is to complete a longitudinal study to determine whether the impression of rapid progression of ECIMT in patients with CAD compared to control subjects without CAD is correct. A second purpose of the study is to quantify the magnitude of the overall effect as well as the segment specific effect in men and women as it is influenced by baseline risk factors and baseline ECIMT. Another question of importance is whether rapid progression of ECIMT leads to reduction of the lumen diameter. Recent studies by this group have suggested that there may be a complex relationship between ECIMT and lumen size. The proposal is for completion of a longitudinal study of a group of men and women with and without CAD for a total of 3 years of follow-up. The first Specific Aim is to obtain 3 year progression rates of ECIMT in the previously accessed cohort of 280 subjects. For this Aim, the method of measuring ECIMT will remain constant for the 3 years of the study and will involve the use of visual measurements. The second Specific Aim is to utilize a new edge detection algorithm to measure the ultrasound studies that have already been performed as well as those that would be completed for Specific Aim 1. This method allows measurement of both lumen diameter and ECIMT. This measurement technique will be applied to baseline studies and the last follow-up study. A third aim, although not specifically stated, is to compare the visual and edge-detection method. This will provide a check on the potential for "drift" in the visual measurements made over the course of the study. The subjects for this investigation are currently being followed.

描述：（改编自研究者摘要）这是一个修订

项目成果

Smoking cessation in relation to cardiac procedures.

戒烟与心脏手术有关。

• DOI: 10.1093/oxfordjournals.aje.a116146
• 发表时间: 1991
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Crouse3rd,JR;Hagaman,AP
• 通讯作者: Hagaman,AP

Individual variation in susceptibility to extracranial carotid atherosclerosis.

颅外颈动脉粥样硬化易感性的个体差异。

• DOI: 10.1161/01.atv.8.4.389
• 发表时间: 1988
• 期刊: Arteriosclerosis (Dallas, Tex.)
• 作者: Rubens,J;Espeland,MA;Ryu,J;Harpold,G;McKinney,WM;Kahl,FR;Toole,JF;Crouse3rd,JR
• 通讯作者: Crouse3rd,JR

Extracranial carotid atherosclerosis in patients with and without transient ischemic attacks and coronary artery disease.

有或没有短暂性脑缺血发作和冠状动脉疾病的患者的颅外颈动脉粥样硬化。

• DOI: 10.1161/01.atv.10.5.714
• 发表时间: 1990
• 期刊: Arteriosclerosis (Dallas, Tex.)
• 作者: Howard,G;Ryu,JE;Evans,GW;McKinney,WM;Toole,JF;Murros,KE;Crouse3rd,JR
• 通讯作者: Crouse3rd,JR

Extracranial carotid atherosclerosis in black and white patients with transient ischemic attacks.

短暂性脑缺血发作的黑人和白人患者的颅外颈动脉粥样硬化。

• DOI: 10.1161/01.str.20.9.1133
• 发表时间: 1989
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Ryu,JE;Murros,K;Espeland,MA;Rubens,J;McKinney,WM;Toole,JF;Crouse,JR
• 通讯作者: Crouse,JR

An evaluation of methods for imaging and quantifying coronary and carotid lumen stenosis and atherosclerosis.

冠状动脉和颈动脉管腔狭窄和动脉粥样硬化成像和量化方法的评估。

• 发表时间: 1993
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Crouse3rd,JR;Thompson,CJ
• 通讯作者: Thompson,CJ