GLUCOSE THRESHOLD FOR CEREBRAL DYSFUNCTION DURING HYPOGLYCEMIA IN IDDDM

IDDDM 低血糖期间脑功能障碍的血糖阈值

• 批准号: 6247108
• 负责人: ROBERT S SHERWIN
• 金额: $ 2.68万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6247108
• 关键词: blood glucose; cerebrum; clinical research; cognition disorders; glucose clamp technique; human subject; hypoglycemia; insulin dependent diabetes mellitus; medical complication; psychomotor reaction time; stimulus /response

Clinical observation suggests that cognitive function can remain impaired after hypoglycemia, despite normalization of plasma glucose. To determine that such a delay occurs, and whether it is influenced by the duration of hypoglycemia, we compared P300 latency (prolongatin is a marker of hypoglycemic cognitive dysfunction), after different periods of hypoglycemia. 17 normal volunteers had 2 hypoglycemic clamp studies. Plasma glucose was lowered to 50mg/dl for 60 min or 180 min. P300 latency was measured at baseline, during hypoglycemia and during glucose recovery. All subjects showed P300 prolongation during hypoglycemia, No change was seen during 3 euglycemic control studies. Despite euglycemia restoration, P300 latency remained prolonged in 13/17 subjects following the 60 min hypoglycemic clamp and all subjects after 180 min of hypoglycemia. The delay was related to the duration of preceding hypoglycemia; it was 2217 min after 60 mins and 4916 min after 180 mins of hypoglycemia (p=0.008). We conclude that hypoglycemia induced cognitive impairment continues after normoglycemia is reestablished and the duration of continuing impairment is proportional to the duration of antecedent hypoglycemia.

临床观察表明，认知功能可能会继续受损 低血糖后，尽管血糖正常化。要确定 这样的延迟是否发生，以及它是否受到 低血糖，我们比较了P300潜伏期(延长是一个标志 低血糖认知功能障碍)，在不同时期 低血糖症。17名正常志愿者进行了2项降糖钳夹试验。 将血糖降至50 mg/dl，持续60分钟或180分钟。P300 在基线、低血糖和血糖期间测量潜伏期 恢复。 所有受试者在低血糖时均出现P300延长，无明显变化 在3项正常血糖对照研究中可见。 尽管正常血糖恢复，但P300潜伏期在13/17年仍延长 受试者在60min的降糖钳夹下，所有受试者在60min后 低血糖180分钟。延误与持续时间有关。 低血糖前，60min后2217min，4916min后 低血糖180min(p=0.008)。 我们的结论是，低血糖导致的认知损害在 正常血糖重新建立，持续损害的持续时间 与既往低血糖的持续时间成正比。