MURINE AND HUMAN AUTOIMMUNITY

鼠类和人类自身免疫

• 批准号: 2463771
• 负责人: G M SHEARER
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2463771
• 关键词: HIV envelope protein gp120; HIV infections; antiviral antibody; autoimmunity; cytokine; helper T lymphocyte; human tissue; immunopathology; immunoregulation; laboratory mouse; synthetic peptide; systemic lupus erythematosus

This laboratory has established that the pattern of T helper cell (Th) dysfunction seen in asymptomatic, HIV-seropositive (HIVs+) is also detected in patients with systemic lupus erythematosus (SLE). Thus, there are certain similarities between the immune dysregulation of SLE patients and HIV+ individuals. For example, mice immunized with the 16/6 idiotype exhibit a shift from a dominant type 1 to type 2 cytokine profile as they progress toward SLE. To investigate other possible similarities, we have tested the sera of SLE patients and mice with SLE-like diseases, and have found evidence of antibodies that recognize the gp120 of HIV, as well as certain synthetic peptides of HIV envelope. These results provide further evidence of similar immunodysregulatory events in SLE patients and individuals infected with HIV.

该实验室已经确定，T辅助细胞（Th）的模式 在无症状、HIV血清阳性（HIV+）中观察到的功能障碍也是 在系统性红斑狼疮（SLE）患者中检测到。 因此，在本发明中， SLE的免疫失调与 艾滋病患者和HIV+患者。 例如，用免疫的小鼠 16/6独特型表现出从优势1型向2型细胞因子的转变 随着SLE的进展， 调查其他可能的 相似之处，我们已经测试了SLE患者和小鼠的血清， SLE样疾病，并已发现证据的抗体， HIV的gp 120以及HIV的某些合成肽 信封. 这些结果提供了类似的证据。 SLE患者和感染者的免疫失调事件 感染了艾滋病毒