DETECTION AND ANALYSIS OF H-2 VARIANT CELL LINES FROM MURINE T CELL LYMPHOMAS

起源于BALB/c的S-49 T细胞淋巴瘤的各种株正在 对H-2抗原表达进行了研究。正常BALB/c淋巴细胞 表达H-2Kd、H-2DD和H-2DD抗原。我们发现这五个人 到目前为止研究的S-49淋巴瘤株并不表达所有这些 细胞表面H-2抗原。H-2抗原的表达模式 利用这些细胞作为靶点：(A)抗体和补体；和(B) 细胞毒性T淋巴细胞(CTL)表现出四种不同的H-2d模式 在测试的五条线中表达。该系统可能对 主要组织相容性复合体表达调控的研究 (MHC)抗原，并增加了相对较高的发病率 这些抗原在同一来源的肿瘤细胞系中的调节。

Various lines of the S-49 T cell lymphoma of BALB/c origin are being studied for the expression of H-2 antigens. Normal BALB/c lymphocytes express H-2Kd, H-2Dd, and H-2Dd antigens. We have found that the five lines of the S-49 lymphoma thus far studied do not express all of these cell surface H-2 antigens. The patterns of expression of H-2 antigens using these cells as targets for: (a) antibody and complement; and (b) cytotoxic T lymphocytes (CTL) exhibit four different patterns of H-2d expression in the five lines tested. This system may be of value for investigating regulation of expression of major histocompatibility complex (MHC) antigens, and raises the possibility of a relatively high rate of modulation of these antigens among tumor cell lines of the same origin.