SYNERGISTIC EFFECTS OF MURINE CYTOMEGALOVIRUS AND GRAFT-VERSUS-HOST REACTION

用小鼠巨细胞病毒(MCMV)或 亲代脾细胞(移植物抗宿主反应-GVHR)导致快速 和严重的免疫抑制。接种病毒或亲本 对细胞进行了选择，使其低于严重 免疫抑制。然而，当这两种接种剂混合使用时，严重的 观察免疫抑制情况。此外，给F1小鼠注射黄曲霉毒素 只识别I类MHC决定簇的亲代淋巴细胞不能识别 导致免疫抑制。然而，第一类认可的组合 而MCMV感染会导致严重的免疫抑制。相比之下， II类GVH和MCMV之间没有明显的协同作用。 小鼠感染巨细胞病毒可使自然杀伤(NK)细胞升高 数量和活动。因此，MCMV感染能够增加 骨髓移植的自然抵抗和排斥反应。

Injection of F1 hybrid mice with either murine cytomegalovirus (MCMV) or parental spleen cells (graft-versus-host reaction - GVHR) results in rapid and severe immunosuppression. Inoculation of either the virus or parental cells were selected so that they would be below the threshold for severe immunosuppression. However, when these two inocula were combined, severe immunosuppression was observed. Furthermore, injection of F1 mice with parental lymphocytes that recognize only class I MHC determinants does not result in immune suppression. However, a combination of class I recognition and MCMV infection results in profound immune suppression. In contrast, there was no detectable synergy between class II GVH and MCMV. Infection of mice with MCMV was found to elevate natural killer (NK) cell number and activity. As a consequence MCMV infection was able to augment natural resistance and the rejection of bone marrow grafts.