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CELL MEDIATED IMMUNITY TO HAPTEN MODIFIED SYNGENEIC LYMPHOCYTES IN MICE

CELL MEDIATED IMMUNITY TO HAPTEN MODIFIED SYNGENEIC LYMPHOCYTES IN MICE
小鼠中针对半抗原修饰的同源淋巴细胞的细胞介导的免疫
批准号：
4691755
负责人：
G M SHEARER
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4691755
关键词：
T lymphocyte autologous transplantation cell cell interaction cell mediated cytotoxicity cell population study cell type cellular immunity clone cells cross immunity genetic regulation genetic strain haptens helper T lymphocyte histocompatibility gene immune tolerance /unresponsiveness immunogenetics immunotoxicity major histocompatibility complex membrane activity monoclonal antibody nitrobenzene spleen surface antigens

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中文摘要
翻译
用三硝基苯磺酸(TNP)修饰小鼠脾细胞。 用两种不同的方法对TNP自身修饰细胞进行了检测。第一, 几种针对I类H-2抗原的单抗 测试与TNP修饰的脾细胞的结合。第二，修改后的 以细胞作为刺激物和靶细胞进行体外试验 细胞毒性T淋巴细胞(CTL)对TNP自身的反应。一些抗H-2Kk病毒 不具有其他特异性的单抗表现出与 正常表达KK的细胞。此外，这些与H-2b结合的单抗 TNP修饰的细胞。这些结果与以下模式相似 H-2k小鼠对CTL的优先识别和H-2b对交叉反应CTL的识别 老鼠品系。
英文摘要
Mouse spleen cells were modified with trinitrobenezene sulfonate (TNP), and the TNP-self modified cells were tested in two different ways. First, several monoclonal antibodies (mAbs) specific for class I H-2 antigens were tested for binding to TNP-modified spleen cells. Second, the modified cells were used as stimulator and target cells for in vitro tests for cytotoxic T lymphocyte (CTL) responses to TNP-self. A number of anti-H-2Kk antibodies not mAbs of other specificities exhibited enhanced binding to cells that normally express Kk. Furthermore, these same mAbs bound to H-2b cells modified with TNP. These results parallel the patterns of preferential CTL recognition in H-2k mice and of crossreactive CTL in H-2b mouse strains.
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