DETECTION AND ANALYSIS OF H-2 VARIANT CELL LINES FROM MURINE T CELL LYMPHOMAS

鼠 T 细胞淋巴瘤 H-2 变异细胞系的检测和分析

• 批准号: 4691769
• 负责人: G M SHEARER
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4691769
• 关键词: T lymphocyte; complement; gene expression; immunogenetics; immunoregulation; lymphoma; major histocompatibility complex; mouse leukemia; neoplasm /cancer immunology; tissue /cell culture; tumor antigens

Various lines of the S-49 T cell lymphoma of BALB/c origin are being studies for the expression of H-2 antigens. Normal BALB/c lymphocytes express H-2Kd, H-2Dd, and H-2Dd antigens. We have found that the five lines of the S-49 lymphoma thusfar studied do not express all of these cell surface H-2 antigens. The patterns of expression of H-2 antigens using these cells as targets for: (a) antibody and complement; and (b) cytotoxic T lymphocytes (CTL) exhibit four different patterns of H-2d expression in the five lines tested. This system may be of value for investigating regulation of expression of major histocompatibility complex (MHC) antigens, and raises the possibility of a relatively high rate of modulation of these antigens among tumor cell lines of the same origin. No progress was made in this project during the past year.

正在研究来源于Balb/c的S-49 T细胞淋巴瘤的各种细胞系 研究H-2抗原的表达。 正常BALB/c淋巴细胞 表达H-2Kd、H-2Dd和H-2Dd抗原。 我们发现， 目前研究的S-49淋巴瘤细胞系并不表达所有这些细胞 表面H-2抗原。 H-2抗原的表达模式， 这些细胞作为（a）抗体和补体;和（B）细胞毒性的靶 T淋巴细胞（CTL）在T细胞中表现出四种不同的H-2d表达模式， 测试的五条线路。 该系统可能具有调查价值 主要组织相容性复合体（MHC）表达的调节 抗原，并提出了一个相对较高的利率的可能性， 这些抗原在相同来源的肿瘤细胞系之间的调节。 过去一年，该项目没有取得任何进展。