EFFECTS OF GRAFT VS HOST REACTIONS ON CELL-MEDIATED IMMUNITY
移植物抗宿主反应对细胞介导免疫的影响
基本信息
- 批准号:3813460
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:CD4 molecule CD8 molecule MHC class I antigen T cell receptor T lymphocyte autoantibody biomarker cell components cell mediated lymphocytolysis test colony stimulating factor complement cytolysis cytotoxic T lymphocyte graft versus host disease helper T lymphocyte hematopoietic stem cells hypogammaglobulinemia immunosuppression interleukin 3 laboratory mouse systemic lupus erythematosus thymus
项目摘要
The long-term effects of parent-into-F1 graft-versus-host reaction (GVHR)
was investigated by following splenic T cell markers and function for up to
18 months after GVHR induction. Despite the appearance of adequate numbers
of T cells which expressed the normal compliment of T lymphocyte markers,
these cells still failed to generate MHC self-restricted, CD4-mediated T
helper responses. This defect was not due to suppression or a defect in
antigen-presenting cell function. Analysis of donor chimerism in
parent-into-F1 GVHR indicated three phases of repopulation: an expansion
phase of donor T cells; a phase of host cell destruction; and a donor
repopulation phase in which extensive donor cell repopulation is observed.
Donor T cells that induce GVHR were studied for T cell receptor repertoire
by Vbeta analyses. It was observed that donor T cell expressing the Vbeta
markers of antihost reactivity were selectively expanded during GVHR. Vbeta
analysis was also used to investigate the possible synergy between class I
GVHR and donor-antihost m1s recognition. It was found that donor-antihost
recognition of class I H-2 and m1s(a) resulted in acute GVHR, and
preferential expansion of the Vbeta T cell receptor reactive with m1s(a).
Depletion of these Vbeta T cells resulted in reduced donor chimerism, but
not in abrogation of GVH-induced immune deficiency.
亲本入f1移植物抗宿主反应(GVHR)的长期影响
项目成果
期刊论文数量(0)
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{{ truncateString('G M SHEARER', 18)}}的其他基金
CELL MEDIATED IMMUNITY TO HAPTEN MODIFIED SYNGENEIC LYMPHOCYTES IN MICE
小鼠中针对半抗原修饰的同源淋巴细胞的细胞介导的免疫
- 批准号:
4691755 - 财政年份:
- 资助金额:
-- - 项目类别:
DETECTION AND ANALYSIS OF H-2 VARIANT CELL LINES FROM MURINE T CELL LYMPHOMAS
鼠 T 细胞淋巴瘤 H-2 变异细胞系的检测和分析
- 批准号:
4691769 - 财政年份:
- 资助金额:
-- - 项目类别:
SYNERGISTIC EFFECTS OF MURINE CYTOMEGALOVIRUS AND GRAFT-VERSUS-HOST REACTION
鼠巨细胞病毒与移植物抗宿主反应的协同效应
- 批准号:
3962949 - 财政年份:
- 资助金额:
-- - 项目类别:
IMMUNE STUDIES IN HOMOSEXUAL MEN AT RISK FOR ACQUIRED IMMUNE DEFICIENCY SYNDROME
对有获得性免疫缺陷综合症风险的男同性恋者进行免疫研究
- 批准号:
3939243 - 财政年份:
- 资助金额:
-- - 项目类别:
SYNERGISTIC EFFECTS OF MURINE CYTOMEGALOVIRUS AND GRAFT-VERSUS-HOST REACTION
鼠巨细胞病毒与移植物抗宿主反应的协同效应
- 批准号:
3916407 - 财政年份:
- 资助金额:
-- - 项目类别:
REGULATION OF HUMAN T CELL RESPONSES BY ADHERENT CELLS
贴壁细胞对人类 T 细胞反应的调节
- 批准号:
3939372 - 财政年份:
- 资助金额:
-- - 项目类别:
相似海外基金
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CD4/CD8 分子在 T 细胞特异性中的作用
- 批准号:
3145834 - 财政年份:1990
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