EFFECTS OF GRAFT VS HOST REACTIONS ON CELL-MEDIATED IMMUNITY

移植物抗宿主反应对细胞介导免疫的影响

基本信息

项目摘要

The long-term effects of parent-into-F1 graft-versus-host reaction (GVHR) was investigated by following splenic T cell markers and function for up to 18 months after GVHR induction. Despite the appearance of adequate numbers of T cells which expressed the normal compliment of T lymphocyte markers, these cells still failed to generate MHC self-restricted, CD4-mediated T helper responses. This defect was not due to suppression or a defect in antigen-presenting cell function. Analysis of donor chimerism in parent-into-F1 GVHR indicated three phases of repopulation: an expansion phase of donor T cells; a phase of host cell destruction; and a donor repopulation phase in which extensive donor cell repopulation is observed. Donor T cells that induce GVHR were studied for T cell receptor repertoire by Vbeta analyses. It was observed that donor T cell expressing the Vbeta markers of antihost reactivity were selectively expanded during GVHR. Vbeta analysis was also used to investigate the possible synergy between class I GVHR and donor-antihost m1s recognition. It was found that donor-antihost recognition of class I H-2 and m1s(a) resulted in acute GVHR, and preferential expansion of the Vbeta T cell receptor reactive with m1s(a). Depletion of these Vbeta T cells resulted in reduced donor chimerism, but not in abrogation of GVH-induced immune deficiency.
亲本入f1移植物抗宿主反应(GVHR)的长期影响

项目成果

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G M SHEARER其他文献

G M SHEARER的其他文献

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{{ truncateString('G M SHEARER', 18)}}的其他基金

CELL MEDIATED IMMUNITY TO HAPTEN MODIFIED SYNGENEIC LYMPHOCYTES IN MICE
小鼠中针对半抗原修饰的同源淋巴细胞的细胞介导的免疫
  • 批准号:
    4691755
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
DETECTION AND ANALYSIS OF H-2 VARIANT CELL LINES FROM MURINE T CELL LYMPHOMAS
鼠 T 细胞淋巴瘤 H-2 变异细胞系的检测和分析
  • 批准号:
    4691769
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
CELLULAR IMMUNE FUNCTION IN AIDS AND CANCER
艾滋病和癌症中的细胞免疫功能
  • 批准号:
    6100958
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SYNERGISTIC EFFECTS OF MURINE CYTOMEGALOVIRUS AND GRAFT-VERSUS-HOST REACTION
鼠巨细胞病毒与移植物抗宿主反应的协同效应
  • 批准号:
    3962949
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
IMMUNE STUDIES IN HOMOSEXUAL MEN AT RISK FOR ACQUIRED IMMUNE DEFICIENCY SYNDROME
对有获得性免疫缺陷综合症风险的男同性恋者进行免疫研究
  • 批准号:
    3939243
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SYNERGISTIC EFFECTS OF MURINE CYTOMEGALOVIRUS AND GRAFT-VERSUS-HOST REACTION
鼠巨细胞病毒与移植物抗宿主反应的协同效应
  • 批准号:
    3916407
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MURINE AND HUMAN AUTOIMMUNITY
鼠类和人类自身免疫
  • 批准号:
    2463771
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
T CELL IMMUNE DYSREGULATION IN CANCER
癌症中的 T 细胞免疫失调
  • 批准号:
    3774434
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MURINE AND HUMAN AUTOIMMUNITY
鼠类和人类自身免疫
  • 批准号:
    6161062
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
REGULATION OF HUMAN T CELL RESPONSES BY ADHERENT CELLS
贴壁细胞对人类 T 细胞反应的调节
  • 批准号:
    3939372
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

ROLE OF CD4/CD8 MOLECULE IN T CELL SPECIFICITY
CD4/CD8 分子在 T 细胞特异性中的作用
  • 批准号:
    3145834
  • 财政年份:
    1990
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ROLE OF CD4/CD8 MOLECULE IN T CELL SPECIFICITY
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  • 批准号:
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ROLE OF CD4/CD8 MOLECULE IN T CELL SPECIFICITY
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  • 批准号:
    3145835
  • 财政年份:
    1990
  • 资助金额:
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