课题基金 / 基金详情

MURINE AND HUMAN AUTOIMMUNITY

MURINE AND HUMAN AUTOIMMUNITY
鼠类和人类自身免疫
批准号：
6161062
负责人：
G M SHEARER
金额：
$0.0万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6161062
关键词：
HIV envelope protein gp120 HIV infections antiviral antibody autoimmunity cytokine helper T lymphocyte human tissue immunopathology immunoregulation laboratory mouse synthetic peptide systemic lupus erythematosus

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中文摘要
翻译
该实验室已经确定，T辅助细胞（Th）的模式 在无症状、HIV血清阳性（HIV+）中观察到的功能障碍也是 在系统性红斑狼疮（SLE）患者中检测到， SLE的鼠模型。这两种诱导的SLE小鼠模型是 比较了抗性和易感性的遗传学。两者 移植物与宿主和16/6 Id SLE诱导模型绘制了遗传图谱 对7号和14号染色体上的基因易感。这些发现表明 SLE是由两种完全不同的方案和机制引起的， 导致抗性和易感性由相同的基因控制。
英文摘要
This laboratory has established that the pattern of T helper cell (Th) dysfunction seen in asymptomatic, HIV-seropositive (HIVs+) is also detected in patients with systemic lupus erythematosus (SLE), and in two murine models of SLE. These two induced murine models of SLE were compared for the genetics of resistance and susceptibility. Both the graft-vs-host- and the 16/6 Id SLE-induced models mapped genetic susceptibility to genes on chromosomes 7 and 14. These findings indicate that SLE induced by two completely different protocols and mechanisms results in control of resistance and susceptibility by the same genes.
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