MURINE AND HUMAN AUTOIMMUNITY

鼠类和人类自身免疫

• 批准号: 6161062
• 负责人: G M SHEARER
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161062
• 关键词: HIV envelope protein gp120; HIV infections; antiviral antibody; autoimmunity; cytokine; helper T lymphocyte; human tissue; immunopathology; immunoregulation; laboratory mouse; synthetic peptide; systemic lupus erythematosus

This laboratory has established that the pattern of T helper cell (Th) dysfunction seen in asymptomatic, HIV-seropositive (HIVs+) is also detected in patients with systemic lupus erythematosus (SLE), and in two murine models of SLE. These two induced murine models of SLE were compared for the genetics of resistance and susceptibility. Both the graft-vs-host- and the 16/6 Id SLE-induced models mapped genetic susceptibility to genes on chromosomes 7 and 14. These findings indicate that SLE induced by two completely different protocols and mechanisms results in control of resistance and susceptibility by the same genes.

本实验室已确定辅助性T细胞（Th）的模式