T CELL IMMUNE DYSREGULATION IN CANCER

癌症中的 T 细胞免疫失调

• 批准号: 3774434
• 负责人: G M SHEARER
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774434
• 关键词: Hodgkin's disease; helper T lymphocyte; histocompatibility antigens; human subject; immunoregulation; immunosuppression; isoantigen; leukocyte activation /transformation; mitogens; neoplasm /cancer immunology; phytohemagglutinins

T helper cell (Th) function was assessed using peripheral blood leukocyte (PBL) from 47 patients newly diagnosed with Hodgkins disease (HD). The PBL were stimulated in vitro with recall antigens (REC), HLA alloantigens (ALLO) and phytohemagglutinin (PHA). Four distinct patterns of Th responsiveness were detected: patients who responded to all three stimuli; patients who did not respond to REC; patients who responded only to PHA; and patients whose PBL were refractory to all three stimuli. The more severely immune-compromised patients exhibited more severe hematologic parameters of HD.

外周血白细胞计数检测辅助性T细胞（Th）功能 (PBL)来自47例新诊断为霍奇金斯病（HD）的患者。 的 用回忆抗原（REC）、HLA同种抗原（HLA-A）和免疫球蛋白（IgG）刺激外周血淋巴细胞（PBL）， （ALLO）和植物血凝素（PHA）。 四种不同的Th模式 检测反应性：对所有三种刺激都有反应的患者; REC无反应的患者;仅对PHA有反应的患者; 和PBL对所有三种刺激均不敏感的患者。 越 严重免疫功能低下的患者表现出更严重的血液学 HD参数