How the red blood cell loses its nucleus
How the red blood cell loses its nucleus
批准号:
DP190103634
负责人:
Prof Patrick Humbert
金额:
$35.59万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-09-01 至 2023-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This project aims to provide insights into erythroid enucleation, the process by which red blood cells extrude their nucleus so that they can circulate through the microvasculature. Although the enucleated character of mammalian red blood cells has been known for more than 150 years, the mechanism underlying this process is virtually unknown. This project will use a live imaging approach to characterise in vivo the cellular interactions and molecular pathways required for enucleation. The project will provide a molecular and cellular road map of enucleation that may be utilised to enhance the bulk therapeutic in vitro production of red blood cells for veterinary and human purposes.
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依托单位:
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