How the red blood cell loses its nucleus

红细胞如何失去细胞核

• 批准号: DP190103634
• 负责人: Prof Patrick Humbert
• 金额: $ 35.59万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-09-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103634
• 关键词: How; red; blood; cell; loses

This project aims to provide insights into erythroid enucleation, the process by which red blood cells extrude their nucleus so that they can circulate through the microvasculature. Although the enucleated character of mammalian red blood cells has been known for more than 150 years, the mechanism underlying this process is virtually unknown. This project will use a live imaging approach to characterise in vivo the cellular interactions and molecular pathways required for enucleation. The project will provide a molecular and cellular road map of enucleation that may be utilised to enhance the bulk therapeutic in vitro production of red blood cells for veterinary and human purposes.

该项目旨在深入了解红细胞去核，即红细胞挤出细胞核以便它们可以在微血管系统中循环的过程。尽管人们对哺乳动物红细胞的去核特性已有 150 多年的了解，但这一过程背后的机制实际上尚不清楚。该项目将使用实时成像方法来表征体内细胞相互作用和去核所需的分子途径。该项目将提供去核的分子和细胞路线图，可用于增强用于兽医和人类目的的红细胞的体外大量治疗性生产。