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Disorderly conduct and disturbing the peace: how loss of cell polarity and tissue architecture drives cancer progression

Disorderly conduct and disturbing the peace: how loss of cell polarity and tissue architecture drives cancer progression
行为不检和扰乱和平:细胞极性和组织结构的丧失如何驱动癌症进展
批准号:
nhmrc : 1079133
负责人:
Prof Patrick Humbert
金额:
$42.58万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2019-12-31

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中文摘要
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英文摘要
Disorganisation of cells within tumours is a defining feature of aggressive cancers. Using mouse models and 3D organ cultures we have now shown that disruption of a family of organising genes found in every cell confuses the arrangement, orientation and connection of cells within an organ thus causing tumours. Here we will provide a new understanding of how the disorganisation of cells in human tissue leads to cancer and develop new cancer therapeutic approaches to keep tissues well-organised.
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A flow cytometry suite for multiscale biosorting
  • 批准号:
    LE220100185
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $45.01万
  • 财政年份:
    2022
  • 负责人:
    Prof Patrick Humbert
  • 依托单位:
How the red blood cell loses its nucleus
  • 批准号:
    DP190103634
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $35.59万
  • 财政年份:
    2019
  • 负责人:
    Prof Patrick Humbert
  • 依托单位:
Cellular and Molecular Characterization of Erythroid Enucleation
  • 批准号:
    nhmrc : 1103858
  • 项目类别:
    Project Grants
  • 资助金额:
    $46.06万
  • 财政年份:
    2016
  • 负责人:
    Prof Patrick Humbert
  • 依托单位:
Cellular and Molecular Characterization of Erythroid Enucleation
  • 批准号:
    nhmrc : GNT1103858
  • 项目类别:
    Project Grants
  • 资助金额:
    $67.2万
  • 财政年份:
    2016
  • 负责人:
    Prof Patrick Humbert
  • 依托单位:
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