Disorderly conduct and disturbing the peace: how loss of cell polarity and tissue architecture drives cancer progression

行为不检和扰乱和平：细胞极性和组织结构的丧失如何驱动癌症进展

• 批准号: nhmrc : 1079133
• 负责人: Prof Patrick Humbert
• 金额: $ 42.58万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/disorderly-conduct-disturbing-cancer-progression/518632
• 关键词: Disorderly; conduct; disturbing; peace; how

Disorganisation of cells within tumours is a defining feature of aggressive cancers. Using mouse models and 3D organ cultures we have now shown that disruption of a family of organising genes found in every cell confuses the arrangement, orientation and connection of cells within an organ thus causing tumours. Here we will provide a new understanding of how the disorganisation of cells in human tissue leads to cancer and develop new cancer therapeutic approaches to keep tissues well-organised.

肿瘤内细胞的解体是侵袭性癌症的一个定义特征。使用小鼠模型和3D器官培养，我们现在已经证明，在每个细胞中发现的组织基因家族的破坏会混淆器官内细胞的排列，方向和连接，从而导致肿瘤。在这里，我们将提供一个新的理解，如何在人体组织中的细胞解体导致癌症，并开发新的癌症治疗方法，以保持组织良好的组织。