Understanding the regulation of cell polarity in development and cancer

了解发育和癌症中细胞极性的调节

• 批准号: nhmrc : 566607
• 负责人: Prof Patrick Humbert
• 金额: $ 28.58万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-regulation-cell-development-cancer/116007
• 关键词: Understanding; regulation; cell; polarity; development

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.

细胞极性是细胞在组织或器官中空间定向的属性。我们现在已经证明，Scribble基因是细胞定向的关键调节因子，可能会抑制肿瘤的发展。在这项提案中，我们将结合组织培养研究和新建立的小鼠模型，研究Scribble及其相关分子的破坏如何影响正常发育和促进癌症。这些研究可能为癌症的治疗干预提供新的靶点。