The role of the asymmetric cell division regulator GPSM2 in mammary gland development and breast cancer

不对称细胞分裂调节因子 GPSM2 在乳腺发育和乳腺癌中的作用

• 批准号: nhmrc : 1062103
• 负责人: Prof Patrick Humbert
• 金额: $ 43.18万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-asymmetric-cell-breast-cancer/454959
• 关键词: role; asymmetric; cell; division; regulator

Tissues are built by small populations of progenitor cells which divide unequally to generate different cell types. Recent studies suggest defective progenitor cells are founders of some breast cancers and that progenitor-like cancer cells resist therapy to regenerate tumours. We have shown a progenitor division regulator called GPSM2 controls these cells and inhibits breast cancer. Examination of this new anti-tumour pathway promises to identify therapeutic targets for breast cancer recurrence.

组织是由一小群祖细胞构建的，这些祖细胞不均匀地分裂以产生不同的细胞类型。最近的研究表明，有缺陷的祖细胞是某些乳腺癌的根源，并且类祖细胞的癌细胞会抵抗肿瘤再生的治疗。我们已经证明了一种称为 GPSM2 的祖细胞分裂调节因子控制这些细胞并抑制乳腺癌。对这种新的抗肿瘤途径的检查有望确定乳腺癌复发的治疗靶点。