The role of Scribble in Prostate Cancer

涂鸦在前列腺癌中的作用

• 批准号: nhmrc : 628614
• 负责人: Prof Patrick Humbert
• 金额: $ 40.13万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-scribble-prostate-cancer/77265
• 关键词: role; Scribble; Prostate; Cancer

Every cell in our body has an intrinsic orientation that is controlled by a universal set of genes known as polarity genes. Loss of this orientation is a common and early feature of cancer. We have identified the gene Scribble as a gene that controls cell orientation and is essential to prevent the development of prostate cancer. We propose experiments to discover how Scribble controls prostate cancer and whether it can be used to better predict outcome for prostate cancer patients.

我们身体中的每个细胞都有一个内在的方向，由一组通用的基因控制，称为极性基因。这种定向的丧失是癌症的常见和早期特征。我们已经确定了基因Scribble作为一个基因，控制细胞的方向，是必不可少的，以防止前列腺癌的发展。我们提出实验来发现Scribble如何控制前列腺癌，以及它是否可以用来更好地预测前列腺癌患者的结果。