How do red blood cells enucleate?

红细胞如何去核？

• 批准号: nhmrc : 566919
• 负责人: Prof Patrick Humbert
• 金额: $ 38.8万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/red-blood-cells-enucleate/101100
• 关键词: How; do; red; blood; cells

Removal of the nucleus from red blood cells (enucleation) is essential for proper circulation of red blood cells through the microvasculature and high haemoglobin concentration in the blood. How this fundamental process is achieved is surprisingly poorly understood. Here we propose to investigate how enucleation occurs in light of enucleation being an unusual asymmetric division. These studies are likely to lead to improvements in expansion of human red blood cells in vitro for transfusions.

从红细胞中去除细胞核（去核）对于红细胞通过微血管系统的适当循环和血液中的高血红蛋白浓度是必不可少的。这一基本过程是如何实现的，人们对此知之甚少。在这里，我们建议调查如何去核发生在光去核是一个不寻常的不对称分裂。这些研究可能会改善体外输血中人类红细胞的扩增。