Molecular Regulation of tumourigenesis by the polarity determinant Scribble and associated proteins

极性决定子 Scribble 和相关蛋白对肿瘤发生的分子调节

• 批准号: nhmrc : 1004434
• 负责人: Prof Patrick Humbert
• 金额: $ 40.97万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-regulation-tumourigenesis-associated-proteins/109033
• 关键词: Molecular; Regulation; tumourigenesis; polarity; determinant

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have shown that Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble promotes breast cancer using a combination of tissue culture studies and a newly established mouse model. Understanding how this new pathway can regulate breast tumour development may provide novel targets for therapeutic intervention in cancer.

细胞极性是细胞在组织或器官中空间定向的特性。我们已经证明Scribble，一种关键的细胞方向调节剂，可以控制肿瘤的发展。在这个提议中，我们将结合组织培养研究和新建立的小鼠模型来研究Scribble的破坏是如何促进乳腺癌的。了解这一新途径如何调节乳腺肿瘤的发展可能为癌症治疗干预提供新的靶点。