The role of the asymmetry gene GPSM2 in breast cancer

不对称基因GPSM2在乳腺癌中的作用

• 批准号: nhmrc : GNT1062103
• 负责人: Prof Patrick Humbert
• 金额: $ 62.62万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-asymmetry-gene-breast-cancer/1344797
• 关键词: role; asymmetry; gene; GPSM2; breast

Tissues are built by small populations of progenitor cells which divide unequally to generate different cell types. Recent studies suggest defective progenitor cells are founders of some breast cancers and that progenitor-like cancer cells resist therapy to regenerate tumours. We have shown a progenitor division regulator called GPSM2 controls these cells and inhibits breast cancer. Examination of this new anti-tumour pathway promises to identify therapeutic targets for breast cancer recurrence.

组织是由一小群祖细胞组成的，这些祖细胞分裂不均匀，产生不同的细胞类型。最近的研究表明，有缺陷的祖细胞是一些乳腺癌的始祖细胞，并且祖细胞样癌细胞抵抗治疗以再生肿瘤。我们已经证明了一种叫做GPSM2的祖细胞分裂调节因子控制这些细胞并抑制乳腺癌。检查这种新的抗肿瘤途径有望确定乳腺癌复发的治疗靶点。