Disorderly conduct and disturbing the peace: how loss of cell polarity and tissue architecture drives cancer progression
Disorderly conduct and disturbing the peace: how loss of cell polarity and tissue architecture drives cancer progression
批准号:
nhmrc : GNT1079133
负责人:
Prof Patrick Humbert
金额:
$61.16万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 --
中文摘要
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英文摘要
Disorganisation of cells within tumours is a defining feature of aggressive cancers. Using mouse models and 3D organ cultures we have now shown that disruption of a family of organising genes found in every cell confuses the arrangement, orientation and connection of cells within an organ thus causing tumours. Here we will provide a new understanding of how the disorganisation of cells in human tissue leads to cancer and develop new cancer therapeutic approaches to keep tissues well-organised.
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The function of polarity regulators in cancer
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Regulation of epithelial migration by Scribble in development and wound repair
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The Role of RB/E2F pathway in cell cycle control and erythropoiesis
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Transcriptional and cell cycle control of erythropoiesis by E2F4
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依托单位:
海外基金