Characterising the lipid droplet-mitochondria proteome

脂滴线粒体蛋白质组的表征

• 批准号: DP180102935
• 负责人: Prof Matthew Watt
• 金额: $ 31.29万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102935
• 关键词: Characterising; lipid; droplet; mitochondria; proteome

This project aims to determine the mechanisms by which the mitochondria and lipid droplets associate, and how this interaction influences lipid metabolism. Both critical for survival, lipid droplets are the bulk energy store in cells and the mitochondria break down this lipid to generate energy. It is anticipated that this project will identify the proteins that are critical for regulating contact between these organelles and the consequences if this process becomes dysregulated. The project expects to provide fundamental new knowledge in understanding how organelles interact and how lipid metabolism is regulated. This knowledge has applications for the primary industries and biotechnology sector.

该项目旨在确定线粒体和脂滴缔合的机制，以及这种相互作用如何影响脂质代谢。这两种对生存都至关重要，脂滴是细胞中的大量能量储存，线粒体分解这种脂质以产生能量。预计该项目将确定对调节这些细胞器之间的接触至关重要的蛋白质，以及如果该过程失调的后果。 该项目预计将为理解细胞器如何相互作用以及脂质代谢如何调节提供基础新知识。这些知识可应用于初级产业和生物技术部门。