Circulating ceramides, inflammation and insulin resistance

循环神经酰胺、炎症和胰岛素抵抗

• 批准号: nhmrc : 546027
• 负责人: Prof Matthew Watt
• 金额: $ 23.89万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/circulating-ceramides-inflammation-insulin-resistance/76122
• 关键词: Circulating; ceramides; inflammation; insulin; resistance

Ceramides are a type of fat that are stored in the body. When people store too many ceramides in their muscles and liver they no longer respond normally to insulin, which leads to the development of type 2 diabetes. Ceramide levels are increased in the blood of people with type 2 diabetes. The aim of the this project is to determine whether ceramides in the blood contribute to type 2 diabetes and whether reducing ceramide levels in the blood improves health.

神经酰胺是一种储存在体内的脂肪。当人们在肌肉和肝脏中储存过多的神经酰胺时，他们不再对胰岛素产生正常反应，从而导致2型糖尿病的发展。2型糖尿病患者血液中的神经酰胺水平升高。该项目的目的是确定血液中的神经酰胺是否会导致2型糖尿病，以及降低血液中的神经酰胺水平是否会改善健康。