Regulation of insulin sensitivity by reactive oxygen species

活性氧调节胰岛素敏感性

• 批准号: nhmrc : 606604
• 负责人: Prof Matthew Watt
• 金额: $ 37.65万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-insulin-sensitivity-oxygen-species/98263
• 关键词: Regulation; insulin; sensitivity; reactive; oxygen

In morbid obesity and type 2 diabetes chronic levels of reactive oxygen species (ROS) are detrimental and diminish insulin's ability to maintain normal blood glucose levels. Paradoxically, ROS also promote insulin action by inhibiting enzymes known as protein tyrosine phosphatases (PTPs). This proposal will determine whether the promotion of ROS for the inhibition of PTPs early in the progression of type 2 diabetes may be of therapeutic benefit.

在病态肥胖症和2型糖尿病中，慢性水平的活性氧簇(ROS)是有害的，并削弱了胰岛素维持正常血糖水平的能力。矛盾的是，ROS还通过抑制蛋白质酪氨酸磷酸酶(PTPs)来促进胰岛素的作用。这项建议将确定在2型糖尿病进展早期促进ROS抑制PTPs是否对治疗有益。