Curing fatty muscles: understanding the role of PLIN5 in lipid metabolism and tissue function

治愈脂肪肌肉：了解 PLIN5 在脂质代谢和组织功能中的作用

• 批准号: nhmrc : 1047138
• 负责人: Prof Matthew Watt
• 金额: $ 30.82万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/curing-fatty-muscles-tissue-function/111914
• 关键词: Curing; fatty; muscles; understanding; role

Diseases associated with the deposition of lipids in muscle are becoming an increasingly important medical problem as the incidence of obesity increases. Skeletal muscle and cardiac function are greatly altered by excessive lipid deposition. The protein PLIN5 is important in regulating fat metabolism. This project aims to determine the functions of PLIN5, how PLIN5 is regulated and whether altering PLIN5 contributes to the development of diabetes and heart failure.

随着肥胖症发病率的增加，与肌肉中脂质沉积相关的疾病正成为日益重要的医学问题。过度的脂质沉积会极大地改变骨骼肌和心脏功能。蛋白质PLIN 5在调节脂肪代谢中很重要。该项目旨在确定PLIN 5的功能，PLIN 5是如何调节的，以及改变PLIN 5是否有助于糖尿病和心力衰竭的发展。