Molecular basis of skeletal muscle lipoapoptosis

骨骼肌脂肪细胞凋亡的分子基础

• 批准号: DP0663443
• 负责人: Prof Matthew Watt
• 金额: $ 17.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663443
• 关键词: Molecular; basis; skeletal; muscle; lipoapoptosis

High levels of fat in cells are associated with obesity and type 2 diabetes, medical conditions that have increased dramatically in prevalence in Australia. High fat levels in cells also causes cell death. This research will determine the mechanisms by which excessive fat storage leads to cell death and whether this leads to insulin resistance and type 2 diabetes. By understanding this relationship, effective pharmaceutical treatments will be developed that will ultimately reduce the incidence of type 2 diabetes, and ease the associated financial burden on the community and healthcare system.

细胞中高水平的脂肪与肥胖和2型糖尿病有关，这些疾病在澳大利亚的流行率急剧上升。细胞中的高脂肪水平也会导致细胞死亡。这项研究将确定过量脂肪储存导致细胞死亡的机制，以及这是否会导致胰岛素抵抗和2型糖尿病。通过了解这种关系，将开发有效的药物治疗，最终降低2型糖尿病的发病率，并减轻社区和医疗保健系统的相关经济负担。